Department of Biology, University of Tikrit, Salah Al-deen, Iraq
Research Article
Histopathological Effect of Ranitidine (Zantac) on Liver and Kidneys in Albino Mice
Author(s): Muna Salah Rashid*
The Purpose: This study was sought to determine the effect of ranitidine on the histological structure of liver and kidneys in the albino mice.
The Design: Two groups of mice were administered Ranitidine 75 mg/kg of and 150 mg/kg respectively, we used (15) albino mice and administrated the doses orally for 10 consecutive 10 days.
Finding: The results showed some structural effects on tissues of liver and kidneys group two showed (75 mg/kg of b.w.) desquamation of the wall of central vein of the liver, necrosis, accumulation of fibroblast, hemorrhage and aggregation of Kupffer cells the kidneys exhibited necrosis in some regions, hemorrhage and existence of cast in the tubules and it seems that ranitidine has caused dilation between glomerulus and bowman corpuscles. Group three (150 mg/kg of b.w.) revealed more dama.. View More»
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