Quality in Primary Care Open Access

Why does the fiction of Alzheimer′s disease perpetuate in neuroscience?

7^th Edition of International Conference on Family Medicine & Primary Care

February 22-24, 2018 Paris, France

Fred C C Peng

Taipei Veterans General Hospital, Taiwan

Posters & Accepted Abstracts: Quality in Primary Care

Abstract:

Introduction: In 2008, the author has raised the question of does Alzheimer�¢����s disease (AD) really exists? The fiction persists in debates on and assertions of prevention of something that does not exist. Author published Alzheimer�¢����s disease: What is it after all? in 2012 to challenge the popular but wrong assumption that AD exists. Purpose: This presentation is to argue that AD is a fiction invented by Emil Kraepelin and the so-called two hallmarks of AD were neither discovered by Alzheimer in 1906 as a new disease nor in 1907 when the case report was published without any histopathological illustrations. The purpose is to set the record straight in the right historical perspective. Conclusion: Author proposes that plaques and tangles can be called as Fischer�¢����s Disease (FD). The change will stop the wild goose chase and encourage neuroscientists to do two things: abandon the notion of MCI, a cheap reinvention of Fischer�¢����s dichotomy: simple dementia and presbyophrenia, and pursue seriously the direction that plaques and tangles are two phases of one pathogenesis hinted by Fischer in 1910-there were no cases with tangles without plaques. However, author modify it with an addendum: it is true if and only if plaques start extracellularly because Pick�¢����s disease (PiD) starts intracellularly and produces tangles without plaques, unless a patient of dementia with PiD has the co-morbidity of FD; therefore, it does not apply to the pathogenesis of PiD or the pathogenesis of Lewy bodies in PD Plus or other pathologies of non-vascular origin with a similar intracellular pathogenesis.