American Journal of Advanced Drug Delivery Open Access

The efficiency of TiO₂ nanoparticles synthesized from Aloe vera leaves extract compared to liposomes as delivery system for doxorubicin: In vivo study using Erlich solid tumor model

Joint Event on 31^st Nano Congress for Future Advancements & 13^th Edition of International Conference on Nanomedicine and Advanced Drug Delivery

August 29-30, 2019 London, UK

Doaa A. Abdelfadeel

Cairo University, Egypt

Posters & Accepted Abstracts: Am J Drug Deliv

Abstract:

Doxorubicin (Dox) is well known for its broad spectrum anticancer activity , however it suffers from sever toxicity. The primary goal of loading Dox in different nanodelivery systems is to decrease nonspecific organ toxicity.

Dox encapsulated liposome (Doxil) has been approved by FDA for ovarian cancer and Kaposi’s sarcoma treatment in United States. However, the researches are still going on to optimize the liposomes and to compare them to other types of nanoparticles.

Titanium dioxide nanoparticles (TiO₂NPs) have been the focus of many promising applications due to their unique properties, low cost, availability and biocompatibility. This study illustrates a simple, safe, low cost and ecofriendly technique for green synthesis of TiO₂NPs from aloe vera leaves extract at different pH values. Doxorubicin was loaded in liposomes and conjugated to greenly synthesized TiO2NPs.Both formula were fully characterized then they have been injected in mice bearing Ehrlich tumor and compared to aquous solution of Dox.Tumor volume measurments and histopathological examinationwere conducted. The results reveled that both formula of Dox were more efficient than aqueous Dox solution, however, Dox encapsulated in liposomes showed more efficiency in treatment of tumor.