Anjana Vasudevan
Sri Ramachandra Medical College and Research Institute, India
Posters & Accepted Abstracts: J Clin Gastroenterol Hepatol
Gastrointestinal stromal tumours (GIST) are non-epithelial (mesenchymal) tumours which are derived due to activating mutations of cKIT(a proto-oncogene called CD117) and less commonly platelet-derived growth factor receptor alpha (PDGFRA). The clinical behaviour is variable, and assessment of the malignancy potential is usually based mainly on the size and the proliferation characteristics of the tumour. Complete surgical excision is the treatment of choice for localized GIST. Most GISTs respond to imatinib mesylate, which selectively inhibits both KIT and PDGFRA, and is now considered as the standard systemic therapy for advanced GIST. Here, we present a 68 year old female who was diagnosed with GIST and underwent sleeve gastrectomy with omentectomy and splenectomy in view of diemmination. Subsequently her histopathology reports suggested high grade spindle cell variant of GIST.
E-mail:
vasudevan_anjana@hotmail.com
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