Interventional Cardiology Journal Open Access

Predictive values of monocyte-derived cytokine response to paclitaxel for the occurrence of in-stent restenosis after coronary paclitaxeleluting stent implantation

EuroSciCon Conference on Clinical Cardiology and Cardiovascular Disease

May 24-25, 2018 London, UK

Kyung-Soo Kim, Yi-Sun Song, Yonggu Lee, Hyun-Woo Joo, In-Hwa Park, Guang-Yin Shen, Jin-Hee Seong, Ki-Sul Chang, Jeong Hun Shin and Hyuck Kim

Hanyang University, South Korea Hanyang University College of Medicine, South Korea Hanyang University Guri Hospital, South Korea

Posters & Accepted Abstracts: Interv Cardiol J

Abstract:

Background: In-stent restenosis (ISR) remains as a major limitation of percutaneous coronary intervention (PCI) even today when drug eluting stent (DES) implantation has become a daily practice. Although some clinical predictors of ISR after DES implantation have been reported, individual’s susceptibility to the eluted drugs has not been investigated as a predictors of ISR. We studied predictive values of monocyte-derived cytokine responses to paclitaxel for ISR after DES implantation. Methods: Peripheral blood was sampled from 110 patients (ISR/non-ISR group, 70/40 patients) who had undergone paclitaxeleluting stent (PES). Coronary angiography was repeated within 2 years after PES implantation to identify the existence of ISR. Monocytes were isolated from the peripheral blood samples, stimulated using lipopolysaccharide, and then treated with paclitaxel. Monocyte-derived cytokine secretion was measured using the Luminex array. The fold increases between pre- and post-paclitaxel exposure cytokine levels were used as the response to paclitaxel. Results: Interleukin-10 (1.3 fold vs. 1.0 fold, p =0.016) and interleukin-12 (2.3 fold vs. 1.7 fold, p =0.002) secretions were higher in the non-ISR group than in the ISR group. In the receiver operating characteristics curves analysis for ISR, the area under the curves were 0.69 and 0.67 for interleukin-10 and interleukin-12, respectively. When the patients were dichotomized using the optimal cut-off point for each cytokine fold increase, ISR less frequently occurred in groups with high fold increases of cytokines including, interleukin-10 (1.1 fold; 50.0% vs. 19.0%, p=0.012), interleukin-12 (2.1 fold; 49.1% vs. 24.6%, p=0.014), interleukin-6 (1.8 fold; 51.4% vs. 29.3%, p=0.009) and interferon-γ (1.3 fold; 43.7% vs. 23.1%, p=0.038). Conclusion: There was a modest predictive value of monocyte derived cytokine response to paclitaxel for ISR after PES implantation. Larger-scale prospective studies are required to confirm the predictive value for paclitaxel and possibly for other drugs eluted on various stents.
Email:kskim@hanyang.ac.kr