Farid Kashwaa
National Cancer Institute - Cairo University, Egypt
Scientific Tracks Abstracts: J Clin Gastroenterol Hepatol
Introduction: Hepatocellular carcinoma (HCC) is a cancer with high mortality. HCC treatment including surgical and loco regional treatment. Recent studies focus on the role of immune system thus immunotherapy represent novel approach to treat HCC because of its immunological characteristic. Curcumin and taurine have been used to participate in HCC through activation of immune system. Materials & Methods: Mononuclear leukocytes and serum were obtained from HCC patients (n=15) baseline then treated oral with curcumin and taurine after three weeks, and six weeks and healthy control (n=30). IL-10, IL-6, IL-8, TNF-α, IFN-γ and TGF-α by ELISA technique and CD4+%, CD8+%, CD4+CD25+%, and CD8+CD25+% by flow cytometery were determined. Results: Results revealed that after treatment for IL-10 there was significant decrease (P<0.05), but for IFN-γ there was significant increase (P<0.01). On contrast, levels of IL-6, IL-8, TNF-α, and TGF-α there were no significant difference (P>0.05). For CD4+%, CD8+%, CD4+CD25+%, and CD8+CD25+% there were significant differences (P<0.0001, P<0.001, P<0.01, and P<0.00001 respectively) compared to baseline. Conclusion: Curcumin and taurine have a protective role against hepatocarcinogenesis
Farid Kashwaa pursued his PhD Degree from Ain Shams University and Postdoctoral studies from National Cancer Institute of Cairo University, Egypt respectively. He is curently a Full Professor of Medical Biochemistry at the same institute since 2011. He has published 25 papers in reputed journals and has been serving as an Editorial Board Member of repute.
E-mail: kashwaa56@yahoo.com
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