Journal of Clinical Gastroenterology and Hepatology Open Access

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Cryptogenic liver cirrhosis in a 22-Year-Old filipino presenting as upper gastrointestinal bleeding: A case report

15th Euro-Global Gastroenterology Conference
June 24-25, 2020 | Webinar

Eleazar Tinio Suguitan

World Citi Medical Center, Philippines

Posters & Accepted Abstracts: J Clin Gastroenterol Hepatol


Distorted liver architecture and regenerative nodules are histologic hallmarks of liver cirrhosis. A variety of risk factors have been associated with development of cirrhosis but cryptogenic cases are still reported. A 22-year-old Filipina was admitted in our institution due two episodes of hematemesis with no other associated signs and symptoms. Patient is a never-drinker and had no previous hepatitis infection. Splenomegaly and mild thrombocytopenia were noted on admission. Endoscopically, Grade IV esophageal varices with signs of recent hemorrhages were noted and rubber band ligation was done. Liver elastography was consistent with cirrhosis. ANA screening was non-reactive but KRT18 was positive. Epidemiology of cryptogenic cirrhosis in young adults is approximately 10% like that of adult population. However, keratin gene mutation causing cirrhosis is rare and associations have not been well elucidated. Young adults at early stages of cirrhosis are clinically asymptomatic and liver architecture is minimally destroyed. Complications leading to major morbidity in cirrhosis are hepatic encephalopathy, spontaneous bacterial peritonitis, esophageal variceal bleeding and ascites in increasing frequency. Thus, we report this case due to the rarity of keratin gene mutation related cryptogenic liver cirrhosis in young adults.