Department of Health Sciences and Professions, The Continents States University, USA
Research Article
Influence of Proton Pump Inhibitors on the Pharmacokinetics and Pharmacodynamics of Selective Serotonin Reuptake Inhibitors
Author(s): Ricky Madison*
Selective Serotonin Reuptake Inhibitors (SSRIs) are used in many psychiatrist issues, no longer confined to tension
and despair. While Proton Pump Inhibitors (PPIs) are generally used to treat gastroesophageal reflux disorder and
peptic ulcers. PPIs have been mentioned to interact with several medicinal drugs due to their impact on gastric pH
and hepatic enzyme pastime. SSRIs are administered through prescriptions whilst most of the PPIs are considered
OTC medications, which causes a primary difficulty for those who take the SSRI’s and use over-the-counter medications
along with PPIs. Pharmacokinetic interactions among PPIs and SSRIs involve changes in drug metabolism and
absorption. PPIs majorly work by way of inhibiting cytochrome P450 enzymes, mainly CYP2C19, which may additionally
influence the metabolism of positive SSRIs tha.. View More»
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