Selective Serotonin Reuptake Inhibitors (SSRIs) are used in many psychiatrist issues, no longer confined to tension
and despair. While Proton Pump Inhibitors (PPIs) are generally used to treat gastroesophageal reflux disorder and
peptic ulcers. PPIs have been mentioned to interact with several medicinal drugs due to their impact on gastric pH
and hepatic enzyme pastime. SSRIs are administered through prescriptions whilst most of the PPIs are considered
OTC medications, which causes a primary difficulty for those who take the SSRI’s and use over-the-counter medications
along with PPIs. Pharmacokinetic interactions among PPIs and SSRIs involve changes in drug metabolism and
absorption. PPIs majorly work by way of inhibiting cytochrome P450 enzymes, mainly CYP2C19, which may additionally
influence the metabolism of positive SSRIs that results in modifications inside the plasma concentrations
and the half-lifestyles. More in particular PPIs can modulate gastric pH, probably influencing the dissolution and
bioavailability of SSRIs, whilst the medical importance of this interplay remains doubtful. On the pharmacodynamic
side, serotonin syndrome, a potentially lifestyles-threatening condition characterized with the aid of excessive
serotonergic activity that’s a subject with concurrent use of SSRIs and PPIs. PPIs can also enhance the hazard of
serotonin syndrome by way of inhibiting the metabolism of SSRIs, main to accelerated serotonin ranges. Clinicians
must be vigilant in monitoring sufferers for signs and symptoms of serotonin syndrome when those medicinal drugs
are co-administered. While there’s proof suggesting capability interactions among PPIs and SSRIs at both pharmacokinetic
and pharmacodynamic stages, in addition studies are warranted to explain the clinical importance and most
effective control strategies of those interactions. Healthcare providers should remember person patient elements,
which includes concomitant medicinal drugs and comorbidities, while prescribing SSRIs and PPIs concurrently, to
reduce the risk of negative consequences and ensure premier therapeutic results.
Keywords: Proton pump inhibitors; Selective serotonin reuptake inhibitors; Pharmacokinetics; Pharmacodynamics;
Drug interactions
Published Date: 2024-03-27; Received Date: 2024-02-28
