Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University,, China
Mini Review
Cracking the Molecular Mechanisms of Oridonin-Induced Reproductive Toxicity: A Multi-Omics Method Using the Wnt/?-Catenin Signaling Pathway as a Target
Author(s): Qibin Gao
Oridonin, a bioactive diterpenoid isolated from the traditional Chinese medicinal herb Rabdosia rubescens, has garnered attention for its anti-cancer, anti-inflammatory, and anti-microbial properties. Despite its therapeutic potential, recent studies have indicated that oridonin may induce reproductive toxicity, raising concerns about its safety, especially in long-term use. Understanding the molecular mechanisms underlying oridonin-induced reproductive toxicity is crucial for mitigating its adverse effects and harnessing its therapeutic benefits. The Wnt/β-catenin signaling pathway plays a critical role in cell proliferation, differentiation, and development. Dysregulation of this pathway has been implicated in various reproductive disorders. Combining advanced omics technologies—proteomics, metabolomics, and epigenetics—offers a comprehensive approach to .. View More»
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