Department of Oncology, Adekunle Ajasin University, Ondo, Akungba, Nigeria
Review Article
Therapeutic Capability of Selected Medicinal Plants Bioactive Constituents against the Mutant Ovarian TP53 Gene; A Computational Approach
Author(s): Koyad Raheem*
Background: The pivotal role of mutant P53 protein in ovarian cancer and the efficacy of natural compounds in cancer treatment necessitated the current study to identify novel mutant P53 modulators from medicinal plants. Homology modelling was deployed to assemble the 3D structure of the mutant P53 protein from its amino acid sequences, while Findsitecom2.0 was used to predict the active binding site of the mutant P53 protein model. The bioactive constituents obtained from seven plants were used as ligands and docked against the binding pocket of mutant P53 protein. Autodock tools, PyRx and discovery studio, were used to prepare the protein, dock the ligands and visualize the complexes, respectively. Thiotepa and germcitabine were used as reference drugs. The hit compounds were selected based on their highest binding affinity and further analyzed to identify their pha.. View More»
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