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The potential biologically active epoxides and hydroperoxides derived from natural monoterpene linalyl acetate as a major ingredient of lavender essential oil

8th Edition of International Conference on Chemical Sciences
June 14-15, 2018 London, UK

Suzan A Khayyat

King Abdulaziz University, Saudi Arabia

Posters & Accepted Abstracts: Arch Chem Res


 Lavender oil, obtained from the flowers of Lavandula angustifolia (Family: Lamiaceae) by steam distillation, The major component of lavender oil is linalyl acetate was isolated and epoxidated thermally and photochemically using (mcpba, H2O2) respectively to produce mixture of 6,7-epoxy-3,7-dimethyl-1-octene-3-yl acetate (3) and 1,2-epoxy-3,7-dimethyl-6-octene-3-yl acetate (4) photochemicaly, While produced epoxide 4 only thermally. On the other hand, photooxygenation of 1 using different singlet oxygen sensitizers gave two hydroperoxide derivatives of 6-hydroperoxy-3, 7-dimethylocta-1,7-diene-3-yl acetate (5)
and 7-hydroperoxy-3,7-dimethylocta-1,5-diene-3-yl acetate (6) in the presence of tetraphenyl porphin (TPP), whereas gave hydroperoxide 6 only using hematoporphyrin (HP). Studies on the antifungal especially Penicillium italicum and Rhizopus stolonifer showed that linalyl acetate and its epoxides and hydroperoxides derivatives have good antibacterial action.