Journal of Infectious Diseases and Treatment Open Access

Synthesis and in-vitro biological Activity some novel 3-Indole propionic acid derivatives

Joint Event on 6^th World Congress and Expo on Applied Microbiology & 8^th Edition of International Conference on Antibiotics, Antimicrobials & Resistance & 12^th International Conference on Allergy & Immunology

October 21-22, 2019 Rome, Italy

Hossein Mostafavi

Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Posters & Accepted Abstracts: J Infec Dis Treat

Abstract:

A diversity of biological activities and pharmaceutical uses have been attributed to 3-Indole propionic acid derivatives such as antibacterial, anticancer, Alzheimer’s disease(1-3). A series of 3-Indole propionic acid were synthesized and their structure confirmed by FT-IR, 1HNMR, 13CNMR, elemental analysis. In vitro biological activity of compounds was evaluated by employing 24 hours cultures of Escherichia coli ATCC (8739), Klebsiella sp. ATCC (700834), bacillus subtilis ATCC (6051) and Staphylococus aureus ATCC (6538). Antibacterial susceptibility tests was done by use of the paper disc diffusion method on Mueller Hinton agar (Merck). Gentamicin was standard reference antibiotics.The inhibition zone was determined by measuring the minimum dimensions of the zone of no microbial growth around the disc. The Minimum Inhibitory Concentrations (MIC) were determined by serial dilution technique according to CLSI. The MIC values of active anti-bacterial compounds 2 and 4 were in the range of 3.25 to 6.5μg/ml concentrations against common bacterial infection causing species.