Asem Anwar Moussa, H A Torky, A Taha, H Marie, E El-Desouky and O Raslan
Glasgow Universities, Egypt
Posters & Accepted Abstracts: Gynecol Obstet Case Rep
Objective and design: Prospective randomized controlled trial to test the effectiveness of topical oxytocin gel to improve vaginal atrophy in postmenopausal women. Patients and methods: A total of 140 postmenopausal women presenting with vaginal atrophy and who satisfied the inclusion and exclusion criteria were randomized into two groups each of 70 patients; they received intravaginal oxytocin gel or placebo gel for 30 days. Serum estrogen level, visual, colposcopic and histological vaginal examination was performed before and after treatment. Results: 47 out of 70 women in the oxytocin gel group improved after treatment and none in the placebo group (p = 0.001). 45 participants in the oxytocin group and seven in the placebo group reported relief of dyspareunia (p = 0.001). 34 participants in the oxytocin group and seven in the placebo group reported relief of soreness (p = 0.001). There was no significant difference between the circulating levels of estradiol in both groups before and after treatment (p = 0.4 and 0.6 for the oxytocin group and the placebo group, respectively). Conclusion: Oxytocin gel is useful in the restoration of the vaginal epithelium in cases of postmenopausal atrophic vaginitis. Further studies with a longer follow-up period are required to test the long-term effects of oxytocin as a treatment for vaginal atrophy.
E-mail:
dramoussa77@hotmail.com
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 