Journal of Infectious Diseases and Treatment Open Access

Phage therapy: A crosslink between human and plants bacterial infection

12^th Edition of International Conference on Infectious Diseases

April 22-23, 2019 Rome, Italy

M Papaianni, A Fulgione and R Capparelli

University of Naples Federico II, Italy

Scientific Tracks Abstracts: J Infec Dis Treat

Abstract:

Bacteria are under constant attack by bacteriophages (phages), the most abundant life forms in the biosphere. This work describes how the phage therapy is an efficient way to contrast the bacterial infection regardless the host. Here, we describe the activity of phage in both plant and chicken meat. All the experiment carried out are with phage complex with the hydroxyapatite, since many years, hydroxyapatite is being explored as vehicle for drug targeting, transfection, bone scaffolds and implant coating materials and for these reasons we evaluated the effect of this mineral for the bacteriophage therapy. At first, we validated the antimicrobial activity of the phage and its possible direct administration into the plant xylem. We next performed both in vivo and in vitro experiments to assess the activity of the bacteriophage in association with hydroxyapatite (Figure 1); secondly, we demonstrate that the hydroxyapatite/ bacteriophage complex was able to reduce the bacterial load of Salmonella Rissen in previously infected minced meat, respective to bacteriophage or hydroxyapatite alone (Figure 2).

Recent Publication

1. Papaianni M, Contaldi F, Fulgione A, Woo S L, Casillo A, Corsaro M M, Parrilli E, Marcolungo L, Rossato M, Delledonne M, Garonzi M, Iannelli D and Capparelli R (2018) Role of phage �?1 in two strains of Salmonella Rissen, sensitive and resistant to phage �?1. BMC microbiology 18(1):208.

2. Carrieri R, Manco R, Sapio D, Iannaccone M, Fulgione A, Papaianni M, de Falco B, Grauso L, Tarantino P, Ianniello F, Lanzotti V, Lahoz E and Capparelli R (2017) Structural data and immunomodulatory properties of a water-soluble heteroglycan extracted from the mycelium of an Italian isolate of Ganoderma lucidum. Natural Product Research 31(18):2119-2125.

3. Papaianni M, Cosenza G, Borriello G, Galiero G, Grasso F, Della Ventura B, Iannaccone M and Capparelli R (2016) The tumor necrosis factor g1022G>A polymorphism is associated with resistance to tuberculosis in water buffalo (Bubalus bubalis). Animal Genetics 48(2):250- 251.

Biography :

M Papaianni received her Bachelor’s Degree from Biology at the University of Naples “Federico II” and Master Degree from Biology at the University of Benevento “Università del Sannio” her study experiences continued thanks to PhD student in Biotechnology of the XXXII cycle. Her scientific curiosity and the strong attitude for research have always allowed me to distinguish myself in my projects.

E-mail: marina.papaianni@unina.it