Polymer Sciences Open Access

L-Alanine induced thermally stable self-healing guar gum hydrogel as potential drug vehicle for sustained release of hydrophilic drug

4^th Edition of International Conference and Exhibition on Polymer Chemistry

March 28-29, 2019 Rome, Italy

Swati Sharma

Institute of Science-Banaras Hindu University, India

Posters & Accepted Abstracts: Polym Sci

Abstract:

Hydrogels are 3D polymeric networks, which are hydrophilic and cross-linked via covalent or noncovalent interactions. Because of their soft nature with similar physical properties to soft tissues attracts more attention in biomedical application but due to its weak mechanical strength and non-healable nature, its application are still restricted in biomedical field. This article introduces a simple approach of preparing self-healable guar gum-graft-acrylic acid (GG-PAA) hydrogel using L-alanine for the first time as a crosslinking agent which alters various properties of hydrogel such as mechanical strength (G’=90,570Pa). A series of guar gum (GG) based hydrogel were synthesized by varying the concentration of L-alanine (from 0.4-1% w/v) which was used as a cross-linking agent. Hydrogel was characterized by HRSEM and rheology studies which explore the morphology and mechanical strength of hydrogel; further it was investigated that synthesized GG based hydrogel showed good swelling ability with excellent self-healing property. The highly water soluble drugs have a tendency to burst rapidly into human body which is undesirable and thus, this hydrogel may be helpful to overcome this problem too and found fruitful applications in biomedical field.

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