Insights in Analytical Electrochemistry Open Access

Formation of solid dispersions famotidine with HPMC E5LV and mannitol with co-grinding technique

Joint Event:8^th Annual Congress on Analytical and Bioanalytical Techniques & 14^th International Conference and Exhibition on Pharmaceutical Formulations

August 28-30, 2017 Brussels, Belgium

Erizal Zaini, Lili Fitriani, Robby Kurniawan and Sherly Ramadhani

Andalas University, Indonesia

Posters & Accepted Abstracts: Insights Anal Electrochem

Abstract:

Solid dispersion have attracted considerable interest as an efficient means of improving the solubility and the dissolution rate of poorly water-soluble drug. The aim of this study was to prepare solid dispersions of famotidine with HPMC E5LV and mannitol as carrier to improve its sollubility and its dissolution rate. Co-grinding techniques by using ball milling was used. 18 formulas with 3 different ratio to HPMC and mannitol (1:1, 1:2, 2:1) and 3 different grinding time (30��?, 60��?, 90��?) were prepared. Characterization of solid dispersion was analyzed with Scanning Electron Microcopy analysis (SEM), X-ray diffraction, Fourier Transform Infrared (FTIR), Optilab Microscope Camera, solubility test and dissolution test. The solid state interaction of coground and physical mixture were evaluated by X-ray powder diffraction and SEM. The dissolution studies were conducted in USP type II apparatus. The result of X-ray powder diffraction analysis showed that the co-ground of famotidine with HPMC E5LV and mannitol decreased the drug crystallinity. X-ray powder diffraction showed the transformation of crystalline state of famotidine to amorphous by co-grinding with HPMC E5LV and mannitol. SEM results showed the co-ground mixture with HPMC E5LV had smaller size and co-ground mixture with mannitol showed agglomerate form. The highest in solubility and dissolution rate was observed for famotidine-HPMC E5LV showed in 1:1 ratio with 90��? grinding time and famotidinemannitol showed in 1:2 ratio with 30��? grinding time compared to the intact famotidine and its physical mixture.