Adane Worku, Rembert Piper, Girmay Medhin and Gobena Ameni
Addis Ababa University, Ethiopia J Craig Venter Institute, Rockville, USA
Posters & Accepted Abstracts: J Prev Infect Cntrol
Introduction: Tuberculosis (TB) is a leading cause of death and became one of the biggest threats to the world. Improvement of its treatment strategies and possibly to reduce drug resistance monitoring and evaluations (M&E) of chemotherapeutic responses are necessary. Objective: To evaluate interferon gamma release assay (IGRA) as a tool for M&E of the efficacy of chemotherapeutic intervention of active TB. Methods: Institutional based prospective longitudinal cohort study design was used. Patients positive for acid fast bacilli stain (AFB), culture and/or GeneXpert MTB/RIF assay were recruited for the study. IGRA was used to evaluate IFN-� response to treatment. Results: The recruited 21 patients had the mean age of 35.5, median 33 and range was 23-56 years. All patients were cured
after the treatment. The mean of the concentration (IU) of IFN-γ response showed decreasing trends from baseline (mean+SD, 2.09+1.09) to the end of the treatment (mean+SD, 0.23+0.20). The patients’ individual baseline IFN-γ concentration had differences and being similar at the end of their treatment. Repeated IFN-ïÂ?© responses had been evaluated for associations between each measurements and showed statistical significance only between two pairs (P<0.001). In this study, IFN-ïÂ?© response to tuberculosis chemotherapeutic intervention was not affected by any of the socio-demographic factors of the study participants (P>0.05). Conclusions: The decreasing trend in IFN-ïÂ?© response following successful anti-TB may have a value as a tool for M&E of the efficacy of chemotherapeutic intervention for active TB. adanewrk@yahoo.com
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