Journal of Alzheimer's & Dementia Open Access

Department of Biotechnology, University of Management and Technology, Sialkot, Pakistan

Publications

• Review Article   
  Apolipoprotein E4 and its Associated Risk to Trigger Alzheimer?s Disease
  Author(s): Faiza Nadeem* and Sajid Ali
  
  Background: Alzheimer’s disease is a common type of age related neurodegenerative disorder characterized by neuronal degeneration and death. The disease can be categorize into three major types, all which share the same symptoms of progressive cognitive impairment, memory loss, and behavioral changes, as well as the same brain pathology of neurofibrillary tangles and amyloid plaques. The age at which each type of Alzheimer’s disease develops is the key factor that distinguishes it from the others. The APOE genotype is the most significant risk factor for late onset Alzheimer’s disease, as it encodes an Apo lipoprotein called apolipoprotein E. The E-gene has three different forms or alleles. The causes of the disease are not fully understood, but both genetics and environmental factors that are believed to play a role. Despite .. View More»
  

  DOI: 10.36648/IPAD.6.4.31

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