Biochemistry & Molecular Biology Journal Open Access

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Ehab Hafiz

Department of Therapeutics, University of Sadat City, Egypt

  • Research Article   
    Is Alfa Feto Protein considered a Hepatocellular Carcinoma Marker or a Hepatocellular Marker ?
    Author(s): Ehab Hafiz*

    Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer- related death worldwide. In the United States, HCC is the ninth leading cause of cancer deaths. Despite advances in prevention techniques, screening, and new technologies in both diagnosis and treatment, incidence and mortality continue to rise. Cirrhosis remains the most important risk factor for the development of HCC regardless of etiology. AFP’s main function is the regulation of fatty acids in both fetal and proliferating adult liver cells.Since 1968, AFP has been used as a serum marker for the detection of HCC (Wong RJ, 2014).Several studies have evaluated the sensitivity and specificity of utilizing AFP with ranges of 21%–64% and 82%–93%, respectively (Colli A, 2000). One major disadvantage is that AFP levels can be falsely raised in patients .. View More»


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