Department of Biological Sciences, Fort Hays State University, Hays, KS, United States of America
Research Article
Effects of RNAi of Ribophorin 1, Eukaryotic translation initiation factor 2 beta, and Peptidylprolyl isomerase A in Acyrthosiphon pisum
Author(s): Brandon Kennemer and James R Balthazor*
Three genes found in the Unfolded protein response, Ribophorin 1, Eukaryotic translation initiation factor 2 beta and peptidylprolyl isomerase a are thought to be potential targets for RNA interference (RNAi) in Acyrthosiphon pisum. Ribophorin 1 (RPN1) is a transmembrane glycoprotein that assists in anchoring ribosomes to the rough endoplasmic reticulum membrane. It acts as a substrate specific chaperone. It facilitates N-glycosylation by delivering newly synthesized proteins to the Oligosaccharyl Transferase (OST) complex. Eukaryotic translation Initiation Factor 2 Beta (eIF2B) is a key component of the eIF2 heterotrimer that facilitates protein synthesis initiation by binding GTP and recruiting a specific transfer RNA to the 40S ribosome. The RNA it recruits is tRNAiMet, which delivers the first methionine to the ribosome to start protein synthesis. eIF2B is part of both the Unfolde.. View More»
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