Journal of the Pancreas Open Access

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Short Communication - (2022) Volume 23, Issue 5

The Current State of Pancreas Transplantation, Gaps in Knowledge
Nicholson Davide*
Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia
*Correspondence: Nicholson Davide, Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia, Email:

Received: 09-May-2022, Manuscript No. IPP-22-13771; Editor assigned: 11-May-2022, Pre QC No. IPP-22-13771(PQ); Reviewed: 25-May-2022, QC No. IPP-22-13771; Revised: 28-May-2022, Manuscript No. IPP-22-13771(R); Published: 31-May-2022, DOI: 10.35841/1590-8577-23.5.747


Rejection of the donor pancreas is one of the most common consequences of a pancreatic transplant. The immune system recognizes the transplanted pancreas as alien and assaults it at this point. Rejection normally happens within a few days or months of the transplant, although it can occur years later. A pancreatic transplant is a difficult and dangerous surgery. Complications may occur if your immune system recognizes the transplanted pancreas as alien and attacks it, or if blood clots develop in the blood arteries that supply the donor pancreas. After a pancreatic transplant, 95 percent of people survive the first year. More than 95% of patients survive the first year after receiving a pancreas transplant. About 1% of patients have organ rejection. After three years, the survival rate drops to 92.5 percent.


All PTx patients had clinical data entered into the Japan Pancreas Transplant Registry of the Japan Society for Pancreas and Islet Transplantation. We used registration data to explain the present state of PTx in Japan. The clinical features of the 410 PTx from dead donors were evaluated by surgeons. Japan has a greater incidence of marginal donors utilizing extended donor criteria than other nations. These rates matched those of other countries. Survival was considerably improved after simultaneous pancreaskidney transplantation (SPK) compared to pancreas-afterkidney transplantation (PAK) or PTx alone when stratified by PTx category (PTA). Immunological rejection was the cause of graft failure in PAK/PTA cases more frequently than in SPK cases, presumably contributing to the worse survival in PAK/PTA [1].

A successful pancreas transplant is the only definitive long-term therapy that both restores euglycemia without the danger of severe hypoglycemia and avoids, halts, or cures secondary problems in patients with type 1 diabetes mellitus and selected individuals with type 2 diabetes mellitus. These advantages are at the expense of extensive surgery and lifetime immunosuppression. Nonetheless, pancreatic transplants are safe and successful, with current patient survival rates. The increased graft survival is due to significant decreases in technical failures and immunologic graft losses. When compared to waiting candidates or patients with diabetes that have a kidney transplant alone, pancreas recipients had a lower death rate. Pancreas recipients had a decreased mortality rate when compared to waiting candidates or individuals with diabetes who got a kidney transplant alone. Pancreas transplants should be given to nonuraemic people with brittle diabetes mellitus more frequently to avoid diabetic complications and the need for a kidney transplant. Despite the use of several organ donor pancreases, islet transplant patients seldom maintain long-term insulin independence. Pancreas and islet transplants should be seen as complementary, rather than mutually incompatible, therapies that are chosen depending on the patient's surgical risk [2].

Diabetes Mellitus (DM) treatment offers various obstacles to healthcare practitioners and accounts for a significant amount of global healthcare cost. Successful pancreas transplantation improves diabetic survival and enables long-term glycemic control. Large single-center research and cumulative analyses of registry data have largely fueled progress in the area. The results of pancreas transplantation for individuals with and without end-stage renal disease are the topic of this review. It discusses the present state of pancreatic transplantation, knowledge gaps, and future research required to allow more patients to benefit from this procedure. One recurring topic is the necessity for multicenter randomized studies in pancreatic transplantation to properly establish effectiveness, hazards, and long-term benefits [3].

Pancreas transplantation in Type 2 Diabetes (T2D) patients is still uncommon compared to pancreas transplantation in Type 1 Diabetes (T1D); however, multiple studies have found similar results in T2D and T1D patients, and the surgery is becoming more widespread. Despite the increased interest in pancreatic transplantation in T2D, no comprehensive review of the evidence has been conducted to date. We conducted a systematic assessment of the literature on T2D pancreas transplantation; including patient and graft survival, glycemic control results, and comparisons with T2D kidney transplant alone and T1D pancreatic transplant recipients. Methodological quality was uneven, with frequent concerns about selection bias and inconsistencies in T2D and pancreatic transplant survival criteria between trials. Overall, studies found that pancreatic transplantation in T2D patients had excellent patient survival, graft survival, and glycemic control results, and there was a need to better describe the T2D patients who would benefit the most from pancreas transplantation. We propose guidelines for future research in order to assist the safe and evidencebased treatment of end-stage T2D and the prudent use of scarce resources [4].

As a result, surgical resection is required. Multiple cysts bordered with cubic flat epithelium containing glycogenrich cells with transparent cytoplasm characterize serous cystic neoplasms. They mostly affect women in their 50s and are usually harmless. As a result, a cautious approach is advised. Because both mucinous cystic neoplasm and intraductal papillary mucinous neoplasms have a high malignant potential, distinguishing between the two pancreatic cystic lesions is critical. A variety of imaging modalities and tumour markers were tested. Despite this, solid criteria for distinguishing serous cystic neoplasms from mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are still lacking. A number of management concerns for these neoplasms are still being debated, such as which imaging technology to employ, how to distinguish between malignant and benign lesions, and which therapy strategy is best for each pancreatic cystic neoplasm. More study could lead to a comprehensive guideline for mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, and serous cystic neoplasms diagnosis and therapy [4].

Pancreas and islet transplants are both treatment possibilities for people with complex type 1 diabetes. Until recently, the results of islet transplantation were considerably lower to those of whole pancreas transplantation. Islet transplantation is typically done alone in patients with severe hypoglycemia, and new registry studies indicate that the outcomes of islet transplantation alone in this indication may be approaching those of pancreas transplantation alone in insulin independence. Looking at the evidence, we believe that, while the pancreas may still be more effective than the islets in weaning patients off insulin, there are significant "gaps" between the two methods that must be considered. These "gaps" concern organ usage, organ allocation, transplant indication, and morbidity. In certain ways, islet transplantation outperforms complete pancreas transplantation, according to in-depth investigation. As a result, efforts should be made on both sides to bridge these gaps in order to attain the same degree of success with any approach. More realistically, some of these gaps are likely to remain, and both methods will coexist and complement each other to guarantee that cell replacement may be effectively adopted in the biggest number of type 1 diabetes patients as feasible [5].


These findings highlight two major issues: a high rate of pancreatic graft loss and poor outcomes following PAK/PTA. Despite the high incidence of marginal donors, the overall outcome of PTx in Japan is good. To enhance results, each source of pancreatic transplant loss must be avoided and managed. To overcome the lower survival rate in PAK/PTA, new immunosuppressive procedures or allogenic islet transplantation may be required.


  1. Tomimaru Y, Eguchi H, Doki Y, Ito T, Kenmochi T. Current state of pancreas transplantation in Japan based on the nationwide registry. Ann Gastroenterol Surg 2021; 5:494-501. [PMID: 34337298].
  2. Indexed at, Google Scholar, Cross Ref

  3. Gruessner RWG, Gruessner AC. The current state of pancreas transplantation. Nat Rev Endocrinol 2013; 9:555-562. [PMID: 23897173].
  4. Indexed at, Google Scholar, Cross Ref

  5. Dean PG, Kukla A, Stegall MD, Kudva YC. Pancreas transplantation. BMJ 2017; 357:j1321. [PMID: 28373161].
  6. Indexed at, Google Scholar, Cross Ref

  7. Amara D, Hansen KS, Kupiec-Weglinski SA, Braun HJ, Hirose R, Hilton JF, et al. Pancreas transplantation for type 2 diabetes: A systematic review, critical gaps in the literature, and a path forward. Transplantation 2022. [PMID: 35576270].
  8. Indexed at, Google Scholar, Cross Ref

  9. Niclauss N, Morel P, Berney T. Has the gap between pancreas and islet transplantation closed?. Transplantation 2014; 98:593-599. [PMID: 25029387].
  10. Indexed at, Google Scholar, Cross Ref

Citation: Davide N. The current state of pancreas transplantation, gaps in knowledge. JOP. J Pancreas. 2022;23(5):747.

Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Competing interests: The authors have declared that no competing interests exist.