Journal of the Pancreas Open Access

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- (2003) Volume 4, Issue 4

Reply to: Helicobacter pylori and Pancreatic Cancer. A Working Hypothesis from Epidemiological Studies

Gianpiero Manes1*, Antonio Balzano1, Dino Vaira2
  1. Department of Gastroenterology, Cardarelli Hospital. Neaples, Italy.
  2. Clinica Medica I, Alma Mater Studiorum - University of Bologna. Bologna, Italy
Corresponding Author: Dino Vaira
Clinica Medica I
Department of Internal Medicine and Gastroenterology
University of Bologna
S. Orsola Hospital, Nuove Patologie
via Massarenti, 9
40138 Bologna
Tel +39-051-636.4140
Fax +39-051-398.794
Received: June 25th, 2003


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Carcinogens; Gram-Negative Bacteria; Helicobacter; Helicobacter pylori; Lymphoma, Mucosa-Associated Lymphoid Tissue; Organisms Category; Pancreatic Diseases; Pancreatic Neoplasms; Risk Factors


Dear Sir,
We thank Dr. Wöhrer and colleagues for their comments [1] on our review article [2] on Helicobacter pylori and the pancreas. The connection between the bacterial infection and pancreatic cancer could become an intriguing field of research. The epidemiological data which exist today are the only such data which support the reliability of this association. The mechanisms by which a chronic Helicobacter pylori infection may favour the onset of pancreatic cancer as well as the fact that curing the infection may reduce the occurrence of the disease in high risk patients (patients with chronic pancreatitis for example) should be the object of further investigations.


  1. Wöhrer S, Hejna M, Raderer M. Helicobacter pylori and pancreatic cancer. A working hypothesis from epidemiological studies. JOP. J Pancreas (Online) 2003; 4:163-164. [PMID 12853685]
  2. Manes G, Balzano A, Vaira D. Helicobacter pylori and pancreatic disease. JOP. J Pancreas (Online) 2003; 4:111-6. [PMID 12743416]