Short Communication - (2022) Volume 23, Issue 1
Received: 20-Dec-2021, Manuscript No. IPP-22-723; Editor assigned: 21-Dec-2021, Pre QC No. IPP-22-723(PQ); Reviewed: 01-Jan-2022, QC No. IPP-22-723; Revised: 12-Jan-2022, Manuscript No. IPP-22-723(R); Published: 19-Jan-2022, DOI: 10.35841/1590-8577-23.1.723
Diversion of pancreatic juice from the duodenum increases both pancreatic flow and protein output in rats. When pancreatic juice was returned to the duodenum, the rise in pancreatic exocrine secretion was significantly reduced. Green and his colleagues hypothesized that endogenous cholecystokinin (CCK) had a role in the exocrine pancreas' negative feedback control. Our study in sedated rats and others in awake animals recently corroborated this. After diversion of pancreatic juice from the duodenum or duodenal administration of pure trypsin inhibitors, plasma concentrations of CCK increased considerably, as assessed by both radioimmunoassay and bioassay using rat pancreatic acini. Immunoneutralization of circulating CCK using rabbit anti-CCK serum or CCK receptor antagonists fully prevented the rise in pancreatic output [1].
Because the increase in protein output caused by pancreatic juice diversion from the duodenum has been accompanied by an increase in pancreatic juice flow (IS), secretin release could be another hormonal mechanism involved in the negative feedback regulation of the exocrine pancreas, in addition to CCK. Secretin stimulates the secretion of water and bicarbonate from the exocrine pancreas. The function of the two hormones produced from the upper small intestine on the exocrine pancreas to emit a higher volume of pancreatic juice and bicarbonate has long been known. In this study, we looked at the function of endogenous secretin in the process of enhanced pancreatic exocrine secretion in fasting rats that had their pancreatic juice diverted.
A control study was conducted. Blood was taken from one group of 10 rats immediately after pancreatic duct cannulation (0 time); another group of 10 rats underwent the identical procedure but without pancreatic duct cannulation (sham operation). Four hours after the surgical surgery, 5-7 cc of blood was taken from each rat in the latter group. Plasma secretin concentration following pancreatic juice diversion. Pancreatic juice was collected by cannula from 60 rats to assess volume and bicarbonate content. The rats were separated into six subgroups, each with ten rats, and blood samples were taken at 0.5, 1, 1.5, 2, 3, and 4 hours after pancreatic juice was diverted to evaluate plasma secretin concentration [2].
Fifty rats were used in the experiment. Each rat was given a test solution to drink for four hours. As a control, the first 10 rats were given 0.15 M NaCl at a rate of 10, 11 and 10 min. The second group of ten rats was given 1.6 mg/1O min of bovine trypsin (Calbiochem). At a concentration of 160 mgiml, trypsin was dissolved in 0.05 M NaHCO. The third group of ten rats received pure pancreatic juice, which had been obtained from donor rats whose pancreatic secretion had been induced by CCK-8 (0.06 pg/kg h) and secretin, at a rate of 10 & 10 min (0.06 Cui/kg h). Both pancreatic juice and bovine trypsin solution were kept at -20°C before use. Twenty rats were used in the fourth round of trials. Because pancreatic juice was diverted from the duodenum in ten rats (recipients), they were given fresh bile-pancreatic juice directly from ten donor rats, all of whom had identical surgical procedures. Donor rat pancreatic cannulas (PE-10) were placed into the second sections of the recipient rat's duodena. Bile was directed instead of traversing the duodenum in the recipient group of ten rats [3].
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Citation: Repicci A. Effects of Biliary and Pancreatic Juice Diversion on Gastrointestinal Motility. JOP. J Pancreas. 2022;23(1):723.
Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Competing interests: The authors have declared that no competing interests exist.
