American Journal of Drug Delivery and Therapeutics Open Access

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Commentary - (2023) Volume 10, Issue 1

Cyclodextrin-Based Nanoparticles for Drug Delivery and Theranostics
Kaixin Wang*
Department of Pharmaceutical, Nagoya University, Japan
*Correspondence: Kaixin Wang, Department of Pharmaceutical, Nagoya University, Japan, Email:

Received: 02-Jan-2023, Manuscript No. IPADT-23-16664; Editor assigned: 04-Jan-2023, Pre QC No. IPADT-23-16664 (PQ); Reviewed: 18-Jan-2023, QC No. IPADT-23-16664; Revised: 23-Jan-2023, Manuscript No. IPADT-23-16664 (R); Published: 30-Jan-2023, DOI: 10.35841/2349-7211.23.10.01


In recent years, the field of nanotechnology has made remarkable strides in various sectors, including medicine. Nanoparticles, which are tiny particles on the nano scale, have emerged as powerful tools in drug delivery systems. These miniature carriers possess unique properties that enable them to overcome the limitations of conventional drug delivery methods. By encapsulating therapeutic agents within nanoparticles, scientists have been able to enhance drug stability, target specific tissues or cells, and improve therapeutic efficacy. This article explores the potential of nanoparticles in drug delivery and their significant impact on the future of medicine. The utilization of nanoparticles in drug delivery holds immense promise for revolutionizing medical treatments. Their small size and large surface area-to-volume ratio provide several advantages, including increased drug loading capacity and prolonged circulation time. Additionally, nanoparticles can protect drugs from degradation and clearance by the body’s immune system, improving their stability and bioavailability. One crucial aspect of nanoparticles is their ability to target specific tissues or cells. By modifying the surface of nanoparticles with targeting ligands, such as antibodies or peptides, drugs can be precisely delivered to diseased sites while minimizing damage to healthy tissues. This targeted drug delivery approach reduces side effects and enhances therapeutic outcomes. Furthermore, nanoparticles can cross biological barriers, such as the blood-brain barrier, which restricts the entry of drugs into the brain. This breakthrough enables the treatment of neurological disorders that were previously challenging to address effectively. Several types of nanoparticles have been explored for drug delivery purposes. Among the most widely studied are liposomes, polymeric nanoparticles, and inorganic nanoparticles. They can encapsulate both hydrophobic and hydrophilic drugs within their core or bilayer structure. Liposomes have excellent biocompatibility and can be tailored to release drugs at a controlled rate. Their flexibility in surface modification allows for targeted drug delivery and simultaneous encapsulation of multiple drugs, enabling combination therapy. Polymeric nanoparticles, made from biocompatible polymers such as poly or polyethylene glycol (PEG), offer numerous advantages. They provide sustained drug release, improved stability, and enhanced cellular uptake. Additionally, the surface of polymeric nanoparticles can be easily modified with ligands to achieve site-specific targeting. Inorganic nanoparticles, including gold nanoparticles and quantum dots, exhibit unique optical, electronic, and magnetic properties. These properties enable imaging, sensing, and targeted therapy. Inorganic nanoparticles can be functionalized with drugs or other therapeutic agents, allowing for precise delivery and controlled release at the desired site.

While nanoparticles show immense promise, several challenges must be addressed before their widespread clinical implementation. One significant concern is the potential toxicity of nanoparticles. Rigorous safety assessments are necessary to ensure the biocompatibility and long-term effects of nanoparticles on the human body. Another challenge lies in scaling up the production of nanoparticles. Current manufacturing processes may be costly and time-consuming, hindering large-scale production. However, on-going research is focused on developing scalable and cost-effective synthesis methods to overcome these limitations. Furthermore, the regulatory framework for nanoparticles in drug delivery needs to be established to ensure their safe and efficient use. It is crucial to define standards for nanoparticle characterization, manufacturing, and quality control, as well as guidelines for clinical trials and approval processes. Looking ahead, the future of nanoparticles in drug delivery appears promising. Advances in nanotechnology continue to push the boundaries of innovation in this field.



Conflict Of Interest

The author’s declared that they have no conflict of interest.

Citation: Wang K (2023) Cyclodextrin-Based Nanoparticles for Drug Delivery and Theranostics. Am J Drug Deliv Ther. 10:01

Copyright: © 2023 Wang K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.