Journal of the Pancreas Open Access

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Xanthogranulomatous Pancreatitis Mimicking Solid Pancreatic Tumor

Nazneen Abdul Kader, NK Supriya, Sathi PP, Prathapan VK

Context Xanthogranulomatous lesion is a rare type of chronic inflammation, in which lipid-laden histiocytes admixed with other inflammatory cells are deposited at various locations in the body. We present a case that was treated by distal pancreatectomy and splenectomy with a clinical and radiological diagnosis of solid tumour panceas, and was found to be xanthogranulomatous pancreatitis on histopathology. Case report A Sixty-five-year-old lady presented with abdominal pain and abdominal mass. Computer tomography and Ultrasound scan confirmed the presence of a soft tissue density mass in the proximal part of pancreas. With the diagnosis of a solid tumour, distal pancreatectomy was performed. Grossly the mass was solid, resembling a neuroendocine tumour and on histopathologic study, was found to be xanthogranulomatous pancreatitis. The cells were strongly positive for CD68. Conclusion Although extremely rare, xanthogranulomatous pancreatitis is an important radiological differential diagnosis for solid tumour of panceas.