Insights in Analytical Electrochemistry Open Access

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Poly(sugar acids): Novel acidic polysaccharide poly[3-(3,4-dihydroxyphenyl)glyceric acid] from medicinal plants of Boraginaceae family, its synthetic analogues and their potential therapeutic efficacy

Vakhtang Barbakadze

Natural polysaccharides have long been studied and widely used in medicine and pharmaceutics. A new polysaccharide is the main chemical constit¬uent of high molecular (>1000 kDa) water-soluble preparations from medicinal plants of Symphytum asperum, S.caucasicum, S.officinale, S.grandiflorum, Anchusa italica, Cynoglossum officinale and Borago officinalis (Boraginaceae) according to data of liquid- state 1H, 13C NMR, 2D 1H/13C HSQC, 2D DOSY and solid-state 13C NMR spectra was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)-ethylene] or poly[3-(3,4-dihydroxyphenyl)-glyceric acid] (PDPGA). The polyoxyethylene chain is the backbone of this biopolymer. 3,4-Dihydroxyphenyl and carboxyl groups are regular substituents at two carbon atoms in the chain. The repeating unit of this regular polyether is 3-(3,4-dihydroxyphenyl)-glyceric acid residue. On the other hand PDPGA as a 3,4-dihydroxyphenyl derivative of poly(2,3-glyceric acid ether) belongs to a class of an acidic polysaccharides [poly(sugar acids)] as well. Its basic monomeric moiety glyceric acid is oxidative form of the aldotriose glyceraldehyde. In this case poly(2,3-glyceric acid ether) chain is the backbone of this polymer molecule and 3,4-dihydroxyphenyl groups are regular substituents at 3C carbon atoms in the chain. Every repeating structural unit of PDPGA contains three reactive functional groups, two phenolic hydroxyl groups in ortho-position and one carboxyl group. Multifunctionality of PDPGA should be a reason of its wide spectrum of biological activities.