Journal of the Pancreas Open Access

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Platinum-Based Therapy in Adenosquamous Pancreatic Cancer: Experience at Two Institutions

Muhammad Wasif Saif, Andre Luiz De Souza

Adenosquamous carcinoma of the pancreas is a rare type of pancreatic cancer. Although its molecular biology profile hasbeen shown to be similar to pancreatic ductal adenocarcinoma tumors, it has different prognostic features. There is noconsensus or guidelines to treat this tumor differently from pancreatic adenocarcinoma, but therapies based on gemcitabineand platinum chemotherapeutics such as cisplatin and oxaliplatin have been used based on results of a few case reports. Wediscuss the Abstract #269 from the 2014 ASCO Gastrointestinal Cancers Symposium showing better outcomes fromplatinum-based therapy in this type of tumors. Triggered by this study, we also present our experience. Prospective studiesto investigate the clinical outcomes from platinum-based therapy and the role of target therapies such as erlotinib arewarranted.