Journal of Clinical Epigenetics Open Access

  • ISSN: 2472-1158
  • Journal h-index: 10
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days


Nutrients that Optimize Aging Brain Functioning: A Systematic Review

Saad Sami Alsogair

Alzheimer’s disease is the most common neurodegenerative disease amongst the elderly population and aging is the most significant factor that is linked to its pathogenesis. Its pathology is characterized by the formation of senile plaques and neurofibrillary tangles, but the exact mechanisms of its progression are still unclear. Oxidative stress and inflammation are considered the major epigenetic factors for aging of the brain and maintaining the redox balance is shown to be crucial in the early development of the disease. A plant-based diet, that is rich in antioxidants and other essential micronutrients have proven to be a successful strategy in fighting oxidative stress and inflammation in the brain. Coupled with caloric restrictions and physical exercises, such a diet can reduce the formation of senile plaques and neurofibrillary tangles and may be used as a preventive therapy for people who are vulnerable to this ailment.