American Journal of Advanced Drug Delivery Open Access

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Neuropharmacological, Analgesic, Antidiarrheal and Antimicrobial Activities of Methanolic Extract of Ziziphus mauritiana Leaves (Rhamnaceae)

Md. Hamiduzzaman, A.S.M. Moniruzzaman Sarkar, Mohammad Jamal Hossain, and Abdur Rashid

The purpose of the present study was to evaluate the neuropharmacological, analgesic, antidiarrheal and antimicrobial activity of methanolic crude extract of Ziziphus mauritiana leaves in mice model. After collection of leaves it was washed, sun dried and made coarse powder. It was soaked in methanol for several days and extracted at room temperature. Dried methanolic extract was partitioned into pet ether, carbon tetrachloride, chloroform and aqueous soluble fractions. Among all the fractions, methanolic extract at a dose of 200 and 400 mg/kg body weight revealed 27.6 and 29.6 minutes of onset of sleeping; 79 and 89.8 minutes of total sleeping time where control group showed 15.8 minutes of onset of sleeping and 118.6 minutes of total sleeping time. Besides crude extract at a dose of 400 mg/kg body weight significantly inhibited the pain sensation at 48.55%, 57.77% and 61.44% after 30, 60 and 90 minutes with respect to standard morphine, revealed antidiarrheal activity by reducing 52.02% of diarrhea comparing with standard drug loperamide (50 mg/kg body wt) having 67.24% of reduction of diarrhea and crude extract and its different fractions inhibited the bacterial growth ranging from 6.5 to 18.8 mm against gram positive bacteria, 6.2 to 17.9 mm against gram negative bacteria and 7.4 to 14.7 mm against fungi compared with standard ciprofloxacin.