Journal of the Pancreas Open Access

  • ISSN: 1590-8577
  • Journal h-index: 80
  • Journal CiteScore: 29.12
  • Journal Impact Factor: 19.45*
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Reach us +44 7460731551


HBV- and HCV-Related Infections and Risk of Pancreatic Cancer

Sirio Fiorino, Andrea Cuppini, Gastone Castellani, Elio Jovine, Maria Letizia Bacchi-Reggiani

Pancreatic carcinoma is one of the most lethal cancers in humans. The poor prognosis of this malignancy depends on several factors, such as: lack of early symptoms, advanced stage at detection, early metastatic spread and no effective systemic treatment. To date, only few risk factors for this malignancy are known; therefore, considerable efforts are required to identify additional causative agents involved in the process of pancreatic carcinogenesis. In the last years, a large series of epidemiological investigations have suggested that both bacteria and viruses may play a important role in the initiation and progression of several animal and human cancers. In particular, some studies have showed that hepatitis B (HBV) andhepatitis C (HCV) viruses, two hepatotropic pathogens with well-known oncogenic properties for liver, may be detected alsoin extra-hepatic tissues, such as pancreas. The aim of this paper is to briefly report the results of available studies, assessingthe possible association between HBV/HCV and pancreatic cancer development as well as to discuss the limiting factors ofthese researches.