In gynecologic malignancies, the intricate tumor microenvironment is a significant modulator of anti-tumor immune responses. The effectiveness of conventional chemotherapy and cutting-edge immunotherapy techniques is significantly impacted by how cancer cells interact with the wide range of immune effector cells. We pay particular attention to the function of macrophages in ovarian, endometrial, and cervical malignancies in this review. We talk about how macrophages developed and how the stimuli from their microenvironment determine their polarization status. Tumor-associated macrophages (TAMs) within the tumor niche influence treatment outcomes by promoting tumor development and mediating immune-suppression. We describe clinical tactics that specifically target TAMs, such as blocking immunological checkpoints, preventing monocyte recruitment to the tumor, enhancing phagocytosis, and inhibiting macrophage differentiation.
Published Date: 2022-08-01; Received Date: 2022-07-06