M Kadiri*, I Benelbarhdadi, M Borahma, FZ Ajana
Aim: Acute hepatitis is a severe inflammation of the liver, with disturbance of markers of liver disease and signs of acute liver failure (jaundice and INR over 1.5), the risk is developing fulminant hepatitis. Our aim is to describe the evolutionary and etiological profile of acute to severe hepatitis.
Materials and methods: A descriptive and retrospective study was conducted on 17 patients who were admitted with an acute and severe hepatitis over a 2 years period.
Results: Autoimmune hepatitis was the main cause of acute hepatitis in 30% of cases (n=5), followed by acute viral hepatitis in 23, 5% of cases (n=4) of which 2 was hepatitis A and 2 was CMV (Cytomegalovirus) hepatitis. DILI (Drug Induced Liver Injury) were found in 17, 6% of cases (n=3) caused by imatinib, carbimazole and antibacillary drugs. In 11, 7% of cases (n=2) it was Wilson’s disease in 2 patients, and alcoholic hepatitis in 2 other patients 11, 7%, and finally in 5,8% (n=1) of cases, a syphilitic hepatitis was diagnosed. Therapeutic management was based on the etiological treatment. Long-term outcome showed a clinical and biological improvement in 70 % of cases (n=12), and a fulminant hepatic failure in 30% (n=5) leading to death in all this cases.
Conclusion: Treatment consists of specific management of the etiology, which must be carried out at an early stage to achieve a satisfactory improvement. In our series the most frequent etiology was autoimmune hepatitis.
Published Date: 2025-01-11; Received Date: 2023-09-06
