American Journal of Advanced Drug Delivery Open Access

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Eco-friendly Synthesis of 3-Chloro -4-(3-Nitrophenyl)-1-Phenyl-azetidin-2-One

Ruhi A. Khan

Recently in this laboratory a new route for the synthesis of azitidinones (6a-g) was developed by eco-friendly reactions to increase the yield of products by maintaining the purity of them. As well as the use of chloroacetyl chloride is a pungent, suffocating odor so, the Eco- friendly method for the synthesis of azetidinone was established. By considering this a novel synthesis of 3-chloro-4-3- nitrophenyl)-1-phenyl-azetidin-2-one (6a-g) were successfully carried out by interacting, N-[(E)-3-nitrophenyl) methylidene] aniline Schiff bases [3a] with triethylamine [4] and chloroacetyl chloride [5] in dioxane medium without any type of refluxion for the synthesis of the azetidinone. The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characteristics, elemental analysis and through spectral data.