To submit a new manuscript authors should use the online submission system
Research in Genes and Proteins Journal publishes original research articles of outstanding medical importance. We will consider manuscripts of any length; we encourage the submission of both substantial full-length bodies of work and shorter manuscripts that report novel findings that might be based on a more limited range of experiments.
The writing style should be concise and accessible, avoiding jargon so that the paper is understandable for readers outside a specialty or those whose first language is not English. Editors will make suggestions for how to achieve this, as well as suggestions for cuts or additions that could be made to the article to strengthen the argument. Our aim is to make the editorial process rigorous and consistent, but not intrusive or overbearing. Authors are encouraged to use their own voice and to decide how best to present their ideas, results, and conclusions. Although we encourage submissions from around the globe, we require that manuscripts be submitted in English. Authors who do not use English as a first language may contact us for additional information. As a step towards overcoming language barriers on acceptance of the paper, we encourage authors fluent in other languages to provide copies of their full articles or abstracts in other languages. We will publish these translations as supporting information and list them, together with other supporting information files, at the end of the article text.
Article Processing Charges (APC):
Research in Genes and Proteins defrays those costs from article-processing charges (APCs) payable by authors once the manuscript has been accepted for publication. Primescholars does not have subscription charges for its research content, believing instead that immediate, world-wide, barrier-free, open access to the full text of research articles is in the best interests of the scientific community.
Average Article processing time (APT) is 45 days
The basic article processing fee or manuscript handling cost is as per the price mentioned above but on the other hand it may vary based on extensive editing, colour effects, tables, complex equations, extra elongation, no. of pages of the article and based on funding, etc.
Organization of the Manuscript
Most articles published in Research in Genes and Proteins will be organized into the following sections: title, authors, affiliations, abstract, introduction, methods, results, discussion, references, acknowledgments, and figure legends. Uniformity in format will help readers and users of the journal. We recognize, however, that this format is not ideal for all types of studies. If you have a manuscript that would benefit from a different format, please contact the editors to discuss this further. Although we have no firm length restrictions for the entire manuscript or individual sections, we urge authors to present and discuss their findings concisely.
Title (max 125 characters)
The title should be specific to the study yet concise, and should allow sensitive and specific electronic retrieval of the article. It should be comprehensible to readers outside your field. Avoid specialist abbreviations if possible. Titles should be presented in title case, meaning that all words except for prepositions, articles, and conjunctions should be capitalized. If the paper is a randomized controlled trial or a meta-analysis, this description should be in the title.
Climate Change and Increased Spread of Malaria in Sub-Saharan Africa A Cluster-Randomized Controlled Trial of a Nurse-Led Intervention after Stroke Please also provide a brief "running head" of approximately 40 characters.
Authors and Affiliations
Provide the first names or initials (if used), middle names or initials (if used), surnames, and affiliations—department, university or organization, city, state/province (if applicable), and country—for all authors. One of the authors should be designated as the corresponding author. It is the corresponding author’s responsibility to ensure that the author list, and the summary of the author contributions to the study are accurate and complete. If the article has been submitted on behalf of a consortium, all consortium members and affiliations should be listed after the Acknowledgments.
(For authorship criteria, see Supporting Information and Materials Required at Submission)
The abstract is divided into the following four sections with these headings: Title, Background, Methods and Findings, and Conclusions. It should contain the all following elements, except for items in square brackets, which are only needed for some study types. Please use the same format for abstracts submitted as presubmission inquiries.
This should be a clear description of the paper's content. The design must be present for randomized controlled trials or systematic reviews or meta-analyses and should be included for other study types if useful.
This section should describe clearly the rationale for the study being done. It should end with a statement of the specific study hypothesis and/or study objectives.
Methods and Findings
Describe the participants or what was studied (eg cell lines, patient group; be as specific as possible, including numbers studied). Describe the study design/intervention/main methods used/What was primarily being assessed eg primary outcome measure and, if appropriate, over what period.
[If appropriate, include how many participants were assessed out of those enrolled eg what was the response rate for a survey.]
[If critical to the understanding of the paper, describe how results were analysed, ie which specific statistical tests were used.]
For the main outcomes provide a numerical result if appropriate (it nearly always is) and a measure of its precision (e.g. 95% confidence interval). Describe any adverse events or side effects.
Describe the main limitations of the study.
Provide a general interpretation of the results with any important recomendations for future research.
[For a clinical trial provide any trial identification numbers and names (e.g. trial registration number, protocol number or acronym).]
The introduction should discuss the purpose of the study in the broader context. As you compose the introduction, think of readers who are not experts in this field. Include a brief review of the key literature. If there are relevant controversies or disagreements in the field, they should be mentioned so that a non-expert reader can delve into these issues further. The introduction should conclude with a brief statement of the overall aim of the experiments and a comment about whether that aim was achieved.
This section should provide enough detail for reproduction of the findings. Protocols for new methods should be included, but well-established protocols may simply be referenced. Detailed methodology or supporting information relevant to the methodology can be published on our Web site.
This section should also include a section with descriptions of any statistical methods employed. These should conform to the criteria outlined by the Uniform Requirements, as follows: "Describe statistical methods with enough detail to enable a knowledgeable reader with access to the original data to verify the reported results. When possible, quantify findings and present them with appropriate indicators of measurement error or uncertainty (such as confidence intervals). Avoid relying solely on statistical hypothesis testing, such as the use of P values, which fails to convey important quantitative information. Discuss the eligibility of research participants. Give details about randomization. Describe the methods for and success of any blinding of observations. Report complications of treatment. Give numbers of observations. Report losses to observation (such as dropouts from a clinical trial). References for the design of the study and statistical methods should be to standard works when possible (with pages stated) rather than to papers in which the designs or methods were originally reported. Specify any general-use computer programs used."
The results section should include all relevant positive and negative findings. The section may be divided into subsections, each with a concise subheading. Large datasets, including raw data, should be submitted as supporting files; these are published online alongside the accepted article. The results section should be written in past tense.
As outlined in the Uniform requirements, authors that present statistical data in the Results section, should "...specify the statistical methods used to analyze them. Restrict tables and figures to those needed to explain the argument of the paper and to assess its support. Use graphs as an alternative to tables with many entries; do not duplicate data in graphs and tables. Avoid nontechnical uses of technical terms in statistics, such as "random" (which implies a randomizing device), "normal," "significant," "correlations," and "sample." Define statistical terms, abbreviations, and most symbols."
The discussion should be concise and tightly argued. It should start with a brief summary of the main findings. It should include paragraphs on the generalisability, clinical relevance, strengths, and, most importantly, the limitations of your study. You may wish to discuss the following points also. How do the conclusions affect the existing knowledge in the field? How can future research build on these observations? What are the key experiments that must be done?
Only published or accepted manuscripts should be included in the reference list. Meetings, abstracts, conference talks, or papers that have been submitted but not yet accepted should not be cited. Limited citation of unpublished work should be included in the body of the text only. All personal communications should be supported by a letter from the relevant authors.
Primescholars uses the numbered citation (citation-sequence) method. References are listed and numbered in the order that they appear in the text. In the text, citations should be indicated by the reference number in brackets. Multiple citations within a single set of brackets should be separated by commas. Where there are three or more sequential citations, they should be given as a range. Example: "...has been shown previously [1,4–6,22]." Make sure the parts of the manuscript are in the correct order for the relevant journal before ordering the citations. Figure captions and tables should be at the end of the manuscript.
Because references will be linked electronically as much as possible to the papers they cite, proper formatting of the references is crucial. Please use the following style for the reference list:
1. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A 74: 5463–5467.
Please list the first five authors and then add "et al." if there are additional authors. Use of a DOI number to the full-text article is acceptable as an alternative to or in addition to traditional volume and page numbers.
Same as above, but "In press" appears instead of the page numbers. Example: Adv Clin Path. In press.
Electronic Journal Articles
1. Loker WM (1996) "Campesinos" and the crisis of modernization in Latin America. Jour Pol Ecol 3. Available: https://www.library.arizona.edu/ej/jpe/volume_3/ascii-lokeriso.txt. Accessed 11 August 2006.
1. Bates B (1992) Bargaining for life: A social history of tuberculosis. Philadelphia: University of Pennsylvania Press. 435 p.
1. Hansen B (1991) New York City epidemics and history for the public. In: Harden VA, Risse GB, editors. AIDS and the historian. Bethesda: National Institutes of Health. pp. 21–28.
People who contributed to the work, but do not fit the criteria for authors should be listed in the Acknowledgments, along with their contributions. You must also ensure that anyone named in the acknowledgments agrees to being so named. Details of the funding sources that have supported the work should be confined to the funding statement. Do not include them in the Acknowledgments.
This section should describe sources of funding that have supported the work. Please also describe the role of the study sponsor(s), if any, in study design; collection, analysis, and interpretation of data; writing of the paper; and decision to submit it for publication.
This section should list specific competing interests associated with any of the authors. If authors declare that no competing interests exist, we will print a statement to this effect.
Please keep abbreviations to a minimum. List all non-standard abbreviations in alphabetical order, along with their expanded form. Define them as well upon first use in the text. Non-standard abbreviations should not be used unless they appear at least three times in the text.
The use of standardized nomenclature in all fields of science and medicine is an essential step toward the integration and linking of scientific information reported in published literature. We will enforce the use of correct and established nomenclature wherever possible:
We strongly encourage the use of SI units. If you do not use these exclusively, please provide the SI value in parentheses after each value.
Species names should be italicized (e.g., Homo sapiens) and the full genus and species must be written out in full, both in the title of the manuscript and at the first mention of an organism in a paper; after that, the first letter of the genus name, followed by the full species name may be used.
Genes, mutations, genotypes, and alleles should be indicated in italics. Use the recommended name by consulting the appropriate genetic nomenclature database, e.g., HUGO for human genes. It is sometimes advisable to indicate the synonyms for the gene the first time it appears in the text. Gene prefixes such as those used for oncogenes or cellular localization should be shown in roman: v-fes, c-MYC, etc.
The Recommended International Non-Proprietary Name (rINN) of drugs should be provided.
All appropriate datasets, images, and information should be deposited in public resources. Please provide the relevant accession numbers (and version numbers, if appropriate). Accession numbers should be provided in parentheses after the entity on first use. Suggested databases include, but are not limited to:
Database of Interacting Proteins
DNA Data Bank of Japan [DDBJ]
EMBL Nucleotide Sequence Database
Gene Expression Omnibus [GEO]
Protein Data Bank
In addition, as much as possible, please provide accession numbers or identifiers for all entities such as genes, proteins, mutants, diseases, etc., for which there is an entry in a public database, for example:
Mouse Genome Database (MGD)
Online Mendelian Inheritance in Man (OMIM)
Providing accession numbers allows linking to and from established databases and integrates your article with a broader collection of scientific information.
If the article is accepted for publication, the author will be asked to supply high-resolution, print-ready versions of the figures. Please ensure that the files conform to our Guidelines for Figure and Table Preparation when preparing your figures for production. After acceptance, authors will also be asked to provide an attractive image to highlight their paper online. All figures will be published under a Creative Commons Attribution License, which allows them to be freely used, distributed, and built upon as long as proper attribution is given. Please do not submit any figures that have been previously copyrighted unless you have express written permission from the copyright holder to publish under the CCAL license.
The aim of the figure legend should be to describe the key messages of the figure, but the figure should also be discussed in the text. An enlarged version of the figure and its full legend will often be viewed in a separate window online, and it should be possible for a reader to understand the figure without switching back and forth between this window and the relevant parts of the text. Each legend should have a concise title of no more than 15 words. The legend itself should be succinct, while still explaining all symbols and abbreviations. Avoid lengthy descriptions of methods.
All tables should have a concise title. Footnotes can be used to explain abbreviations. Citations should be indicated using the same style as outlined above. Tables occupying more than one printed page should be avoided, if possible. Larger tables can be published as online supporting information. Tables must be cell-based; do not use picture elements, text boxes, tabs, or returns in tables. Please ensure that the files conform to our Guidelines for Figure and Table Preparation when preparing your tables for production.
1) When you submit an article; tables and figures must be submitted as separate files
2) Tables must be in Word.doc format
3) Line Graphs should be in or tif or eps formats, and resolution of 900-1200 dpi. If you are unsure about this, please send us the graph in Microsoft excel format and we will convert it into eps or tif formats.
4) Photographs containing no text must be in jpg or tif formats with resolution of 500+ dpi. If you do not have tif or eps, please submit as jpg.
5) Images which contain a combination of text and picture elements must be jpg or tif or eps formats with resolution of 500-1200 dpi. If you do not have tif or eps, please submit as jpg.
**** Generally, we will NOT accept any images with resolution below 300 dpi. You must submit at least in jpg format, that way we can change it into any other format accordingly.
**** Please note that all images must be big (greater than the intended size) and of high resolution.
For more information regarding the image quality requirements, please visit: https://www.ncbi.nlm.nih.gov/pmc/about/PMC_Filespec.html#Image_File_Requirements
Please note that we will be strictly enforcing these conditions and files which fail to conform to these requirements will not be considered for publication.Multimedia Files and Supporting Information
We encourage authors to submit essential supporting files and multimedia files along with their manuscripts. All supporting material will be subject to peer review, and should be smaller than 10 MB in size because of the difficulties that some users will experience in loading or downloading files of a greater size. If your material weights more than 10 MB, please provide it by email: [email protected]
Supporting files should fall into one of the following categories: Dataset, Figure, Table, Text, Protocol, Audio, or Video. All supporting information should be referred to in the manuscript with a leading capital S (e.g., Figure S4 for the fourth supporting information figure). Titles (and, if desired, legends) for all supporting information files should be listed in the manuscript under the heading "Supporting Information."