Waqar Al-Kubaisy, Redhwan A Al-Naggar, Nik Shamsidah Ni, Mustafa Waseem Al-Kubaisi, and Yuri Bobryshev Mustafa Waseem Al-Kubaisi
Faculty of dentistry, Dajilah University, Baghdad, Iraq
Posters & Accepted Abstracts: J Healthc Commun
Background: The medical risk factors associated with hepatitis C virus (HCV) infection such as, blood transfusion and surgery had been studied in many countries. Up to 40% of patients infected with HCV may have non identifiable routes of viral acquisition and tooth extraction may be one of these risk factors. Aim: To determine the existence of HCV infection and the predominated HCV genotype among subjects with tooth extraction. Materials & Methods: A case-control study involving pregnant women with (case=776) and without (control=2715) history of tooth extraction was carried out. HCV antibodies (antiHCV) were tested using subsequently third generation enzyme immunoassay (EIA–3) and immunoblot assay (Lia Tek–111). In addition, 94 serum samples were subjected to molecular analysis, using RT–PCR and DNA enzyme immunoassay (DEIA) method for identification of HCV–RNA and genotypes at Sorin Biomedica in
Italy. Results: Anti-HCV seroprevalence was significantly higher (6.3%) among cases of tooth extraction than in the control group (2.63%), P=0.00001. Tooth extraction was found as a risk factor for HCV infection (OR=2.73, 95% C.I=1.88–3.9). Positive HCV–RNA was significantly higher (74.6%) among cases than in (38.7%) control group (P=0.0016). No significant association was noted between HCV genotypic and the history of tooth extraction. However, HCV1b genotype showed a higher rate (90%) among the subjects with tooth extraction. Conclusion: Patients with dental extraction were shown to be considered as infected and at a risk of acquiring HCV. Therefore, complete sterilization and cleaning of equipment is highly recommended to avoid HCV transmission via dental extraction. mustafaw87@gmail.com
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