Department of Hematology, The Second Affiliated Hospital of Soochow University, No. 1055, San Xiang Road, Gu Su District, Su Zhou City, China, Department of Oncology, Suqian Af, China
Perspective
cGAS Promote DLBCL Survival through IL6-STAT3 and NF-?B Signaling
Author(s): Rui Wang*
Exogenous and endogenous DNA may trigger the Pathogen-Associated Molecular Pattern (PAMP) during infection and the Danger-Associated Molecular Pattern (DAMP) that senses intracellular DNA, thereby activating the evolutionarily conserved cGAS-STING mechanism for inflammatory reactions. The cGAS-STING signaling cascade plays a crucial role in the pathogenesis and progression of numerous clinical conditions, including neurodegenerative, autoimmune, cardiovascular, and neoplastic conditions. Inhibition of cGAS-STING signaling is effective in treating the first three conditions, but there is controversy regarding whether cGAS-STING should be suppressed or activated in cancer therapy. Deregulation of the cGAS-STING signaling pathway may be the cause and pathogenesis of a variety of pathological conditions; therefore, understanding and modulating cGAS-STING signaling holds tremendous promise.. View More»
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