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Perspective - (2022) Volume 8, Issue 9

The Vicious Cycle of Organokines, Sarcopenia, and Metabolic Effects: The Role of Exercise
Fadiji Ayomide*
Department of Chemistry, Rhodes University, South Africa
*Correspondence: Fadiji Ayomide, Department of Chemistry, Rhodes University, South Africa, Email:

Received: 31-Aug-2022, Manuscript No. IPBMBJ-22-14665; Editor assigned: 02-Sep-2022, Pre QC No. IPBMBJ-22-14665 (PQ); Reviewed: 16-Sep-2022, QC No. IPBMBJ-22-14665; Revised: 21-Sep-2022, Manuscript No. IPBMBJ-22-14665 (R); Published: 28-Sep-2022, DOI: 10.36648/2471-8084-8.9.95


Sarcopenia is a disease that is more prevalent as people age because it is closely tied to the senility process, which causes muscle atrophy and loss of muscle strength. Sarcopenia causes various metabolic alterations as well as sarcopenic obesity, also known as sarcopenic obesity, over time. Sarcopenia can either get better or get worse as a result of the molecular effects that organokines have on a range of tissues. Everything is based on how they were created, which is connected to factors like physical activity, ageing, and metabolic illnesses. Given the severity of these effects, the goal of this literature review is to investigate the relationship between organokines, sarcopenia, diabetes, and other metabolic impacts as well as the importance of physical activity.


The 451 million persons worldwide were expected to have diabetes mellitus in 2017. By 2035, this number is projected to increase dramatically, making it more challenging to identify, stop, and treat the condition. Its incidence and prevalence increase with age, and it is associated with musculoskeletal diseases and a sedentary lifestyle. Type 2 diabetes mellitus (T2DM) is characterised by resistance to insulin, increased levels of advanced glycation end products (AGEs), a pro-inflammatory phenotype, and oxidative stress (OS). T2DM can result in micro and macrovascular problems. Obesity, dyslipidemia, and cardiovascular disorders are all closely associated with diabetes (CVD).

Sarcopenia is a disorder that affects older people and is closely related to pro-inflammatory and oxidative settings. The chance of fractures, cardiovascular problems, and a poor quality of life can all negatively affect the prognosis if preventative steps are not done, most importantly staying physically active regularly throughout one’s life.

Organokines aid in understanding the pathophysiology of sarcopenia and the unravelling of its molecular cosmos. Organokines frequently trigger simultaneous crosstalk in many tissues. They thereby shed light on how modifications to certain myokines, adipokines, hepatokines, or osteokines can enhance the clinical state of sarcopenic patients. Given the foregoing, an understanding of organokines can help with the treatment and prevention of sarcopenia and its effects. It can also serve to emphasise the importance of physical activity due to the disease’s best treatment.

Osteokine sclerostin has a role in bone mass formation and regulation, and as was already recognised, its absence causes inherited illnesses of excessive bone mass. It decreases bone mass in diabetics because of a lack of insulin production or resistance. Insulin’s excess is associated with metabolic illnesses even though it increases the quantity and efficiency of osteoblasts, which indirectly controls blood glucose levels. Accordingly, it is asserted that sclerostin has a significant potential to directly implicate sarcopenia and related metabolic consequences.


Myostatin, a molecule that is mostly produced by human skeletal muscle cells, belongs to the TGF-superfamily of growth factors. The physiological actions of this myokine include suppressing muscle development, increasing protein breakdown, and limiting protein synthesis. As a result of these changes, myostatin largely alters extracellular binding proteins of transcriptional and epigenetic control, leading to muscle atrophy and cachexia. Myostatin has also recently been related to obesity, insulin resistance, and cardiovascular disease.

Citation: Ayomide F (2022) The Vicious Cycle of Organokines, Sarcopenia, and Metabolic Effects: The Role of Exercise. Biochem Mol Biol J. 8:95.

Copyright: © 2022 Ayomide F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.