Commentary - (2022) Volume 13, Issue 8
Received: 01-Aug-2022, Manuscript No. AASRFC-22-14430; Editor assigned: 03-Aug-2022, Pre QC No. AASRFC-22-14430 (PQ); Reviewed: 17-Aug-2022, QC No. AASRFC-22-14430; Revised: 22-Aug-2022, Manuscript No. AASRFC-22-14430 (R); Published: 29-Aug-2022, DOI: 10.36648/0976-8610.13.8.83
This narrative study was conducted to assess the use of nanoparticles (NPs) to deliver radionuclides to targets, with a focus on pre-clinical and, when available, clinical delivery systems. The following search phrases were used: “Radionuclides” and “liposomes” or “PLGA nanoparticles” or “gold nanoparticles” or “iron oxide nanoparticles” or “silica nanoparticles” or “micelles” or “dendrimers” in the PubMed and Web of Science data sets. A basic constraint of 10 patients chosen for clinical trials was the only channel that was used.
We now present the information that is available from a few significant pre-clinical and clinical investigations that involved large amounts of data. Each of the selected seven types of nanoparticles was thoroughly tested in clinical trials, however they all generally have a number of drawbacks. Particularly liposomes have been tested for clinical purposes, but they have never gained widespread acceptance. Overall, the use of NPs for imaging has drawn a lot of attention over the long period, mostly in pre-clinical settings. Accordingly, that’s how we think, given the current situation; radiolabeled NPs should be investigated for a longer period of time before being found a place in atomic medicine.
Utilizing nano-sized transporters known as nanoparticles is one method for drug delivery that guides atoms to their destination (NPs). Different NPs, including as polymeric NPs, liposomal transporters, dendrimers, attractive iron oxide NPs, carbon nanotubes, and inorganic metal-based nano-formulations, can be used for this purpose. NPs should be an acceptable size, shape, and surface charge in order to provide a homogeneous conveyance. By using NPs to transport additional payloads, such as hydrophilic or amphiphilic substances, characteristics, and radionuclides, the objective to non-target ratio can be increased.
Overall, NPs have been the focus of numerous studies in atomic medicine over time, especially for imaging purposes. Even though a reasonable strategy of future tests will be necessary, we accept that this area of research has remarkable potential. However, before using them in treatment, their physiological aggregation in the spleen and liver needs to be resolved. Undoubtedly, NPs still primarily use uninvolved concentration and taking advantage of the EPR impact to achieve their goals, but this renders the method of delivery far from clear-cut and from the idea of the enchanted shot. Additionally, additional research should be done on the potential poisonousness of particular types of NP. In this way, it is necessary to enhance the NPs’ design and delivery methods, such as by using pH-sensitive polymers or taking use of proteins that are communicated at the site of the tumour rather than in healthy tissues. Before being deployed in atomic medication simulations, NPs should eventually demonstrate their superiority to the currently employed radionuclide- conveyance professionals once these concerns have been addressed. Finally, a true interpretation of the pre-clinical situation in a clinical sector hasn’t been completed, notwithstanding liposomes. Contrary to what we would want to believe, a few drawbacks, primarily costs and their most recent extension, really prevent the NPs mentioned above from moving further (drug conveyance or radioisotope conveyance). This is why we believe that, given the current situation, further research is necessary before determining where radio labelled NPs would fit into atomic medicine and, ultimately, clinical practise.
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The author declares there is no conflict of interest in publishing this article has been read and approved by all named authors.
Citation: Christian S (2022) Relationship between Radioisotopes and Nanoparticles Pre-clinical and Clinical Investigation. Adv Appl Sci Res. 13:83.
Copyright: © 2022 Christian S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
