Trauma & Acute Care Open Access

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Short Communication - (2023) Volume 8, Issue 3

Neural Signatures of Human Psychological Resilience Driven by Acute Stress
Yue Yu*
Department of Medicine, University of Hong Zhang, China
*Correspondence: Yue Yu, Department of Medicine, University of Hong Zhang, China, Email:

Received: 30-Aug-2023, Manuscript No. IPJTAC-24-19524; Editor assigned: 01-Sep-2023, Pre QC No. IPJTAC-24-19524 (PQ); Reviewed: 15-Sep-2023, QC No. IPJTAC-24-19524; Revised: 20-Sep-2023, Manuscript No. IPJTAC-24-19524 (R); Published: 27-Sep-2023, DOI: 10.36648/2476-2105-8.3.30


Psychological resilience, the ability to adapt and recover from adversity, plays a crucial role in how individuals respond to acute stress. While stress is often perceived negatively, it can also serve as a catalyst for resilience-building processes in the brain. Understanding the neural signatures associated with psychological resilience in the face of acute stress can provide valuable insights into human adaptation and coping mechanisms.


Recent research in neuroscience has shed light on the neural mechanisms underlying psychological resilience. One key area of interest is the brain’s stress response system, which includes structures such as the amygdala, prefrontal cortex, and hippocampus. These regions play distinct roles in processing stressors, regulating emotions, and forming adaptive responses. The amygdala, known for its involvement in emotional processing, reacts rapidly to potential threats, triggering the “fight or flight” response. In individuals with high psychological resilience, there is evidence of enhanced amygdala regulation, allowing for more adaptive emotional responses to stress. This regulation is often linked to increased connectivity between the amygdala and prefrontal regions responsible for cognitive control and emotion regulation. The prefrontal cortex, particularly the ventromedial prefrontal cortex and dorsolateral prefrontal cortex, plays a crucial role in modulating stress responses and decision-making processes. Studies have shown that resilient individuals exhibit greater activation and connectivity within these prefrontal regions during stress, indicating enhanced cognitive control and resilience-promoting strategies such as cognitive reappraisal and problem-solving. Another important brain structure implicated in resilience is the hippocampus, involved in memory formation and stress regulation. Chronic stress is known to have deleterious effects on the hippocampus, leading to structural changes and impaired cognitive function. However, research suggests that acute stress, when managed effectively, can promote hippocampal neuroplasticity and resilience. Resilient individuals may demonstrate preserved hippocampal volume and function, facilitating adaptive responses to stress and promoting recovery. Furthermore, neurotransmitter systems such as dopamine, serotonin, and endogenous opioids play modulatory roles in resilience processes. Dopamine, associated with reward processing and motivation, may contribute to resilience by enhancing goal-directed behavior and positive affect regulation. Serotonin, implicated in mood regulation and stress coping, influences resilience through its effects on emotional stability and stress resilience. Endogenous opioids, involved in pain modulation and stress buffering, contribute to resilience by dampening stress responses and promoting resilience-promoting behaviors. The interaction between genetic factors and environmental influences also shapes neural signatures of resilience. Genetic variations related to stress response pathways, neurotransmitter function, and neuroplasticity can influence an individual’s predisposition to resilience or vulnerability. Environmental factors such as earlylife experiences, social support, and coping strategies further modulate resilience mechanisms, shaping neural adaptations to stress over time [1-4].


In summary the neural signatures of human psychological resilience driven by acute stress involve complex interactions between brain regions, neurotransmitter systems, genetic factors, and environmental influences. Understanding these neural mechanisms can inform targeted interventions aimed at enhancing resilience and mitigating the negative impacts of stress-related disorders. By promoting adaptive stress responses, fostering resilience-promoting behaviors, and providing supportive environments, we can empower individuals to thrive in the face of adversity.



Conflict Of Interest



Citation: Yu Y (2023) Neural Signatures of Human Psychological Resilience Driven by Acute Stress. Trauma Acute Care. 8:30.

Copyright: © 2023 Yu Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.