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Perspective - (2023) Volume 5, Issue 2

Modeling Negative Feedback Physiological Control Systems: A Comprehensive Approach
Isabella Nguyen*
Department of Bioengineering, Vietnam National University, Vietnam
*Correspondence: Isabella Nguyen, Department of Bioengineering, Vietnam National University, Vietnam, Email:

Received: 31-May-2023, Manuscript No. jbtc-23-17005; Editor assigned: 02-Jun-2023, Pre QC No. jbtc-23-17005 (PQ) ; Reviewed: 16-Jun-2023, QC No. jbtc-23-17005; Revised: 21-Jun-2023, Manuscript No. jbtc-23-17005 (R); Published: 28-Jun-2023, DOI: 10.35841/jbtc.23.5.13


Numerical models can work on the comprehension of physiological frameworks conduct, which is an essential point in the bioengineering field. Having a solid model empowers specialists to do in silico tests, which call for less investment and assets contrasted with their in vivo and in vitro partners. This work’s goal is to catch the qualities that a nonlinear dynamical numerical model ought to display, to portray physiological control frameworks at various scales. The likenesses among different negative criticism physiological frameworks have been examined and an interesting general system to portray them has been proposed. Inside such a structure, both the presence and solidness of balance focuses are examined. The model here presented depends on a shut circle geography, on which the homeostatic cycle is based.


To approve the model, three paradigmatic instances of physiological control frameworks are delineated and talked about: The ultra-responsiveness system for accomplishing homeostasis in biomolecular circuits, the blood glucose guideline, and the neuromuscular reflex circular segment (likewise alluded to as muscle stretch reflex). That’s what the outcomes show, by a reasonable decision of the demonstrating capabilities, the powerful development of the frameworks under study can be portrayed through the proposed general nonlinear model. Besides, the investigation of the harmony focuses and elements of the previously mentioned frameworks are predictable with the writing. Numerical models ended up being a strong and significant device to accomplish an exhaustive comprehension of the way of behaving and elements of physiological frameworks, which is a basic point in the bioengineering field; see, for example, the books that, still today, address a foundation for the scientists of the field. Shifting focus over to later times, one can allude to the monographs. For sure, having a solid and exact physiological model empowers specialists to do in silico tests, which call for undeniably less investment and assets contrasted with their in vivo and in vitro partners. The greater parts of the physiological frameworks, taken at their own various scales, demonstrate to have undifferentiated from and covering control elements. It is feasible to consider, as specific illustrations, at the nano-scale, the hereditary circuits for biomolecular process control, portrayed in the important books with their lists of sources, and at the miniature and milli-scale, as the cell populace elements required, for example, in the age and development of cancers and the guideline of rest wake cycles. At long last, models at the full scale level are the control frameworks for the guideline of cardiovascular cycles, neuromuscular exercises, breath elements, and so on.


This class of frameworks consolidates a negative criticism control plot, inside a shut circle design, which allows the upsides of the physiological boundaries to be stayed close to the actual balance to protect the homeostatic harmony. Regardless of whether a physiological control framework and a regular (counterfeit) shut circle negative criticism framework have on a very basic level a similar goal, i.e., coming to and keeping a reference esteem (in any event, not to be a long way from it), their working and execution is somewhat unique. In the previous, the regulator and the plant, whose result should intently match the reference signal, are isolated actually and coherently.

Citation: Nguyen I (2023) Modeling Negative Feedback Physiological Control Systems: A Comprehensive Approach. Bio Eng Bio Electron. 05:13.

Copyright: © 2023 Nguyen I. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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