Commentary - (2022) Volume 3, Issue 6
Received: 30-Nov-2022, Manuscript No. JAC-23-15394 ; Editor assigned: 02-Dec-2022, Pre QC No. JAC-23-15394 (PQ); Reviewed: 16-Dec-2022, QC No. JAC-23-15394 ; Revised: 21-Dec-2022, Manuscript No. JAC-23-15394 (R); Published: 28-Dec-2022, DOI: 10.35841/jac.3.6.26
Eicosanoids are a family of bioactive compounds derived from arachidonic acid that play a central role in physiology and disease, including inflammatory conditions in multiple organ systems. Eicosanoid biosynthesis requires a series of catalytic steps controlled by specific enzymes that can be regulated by inflammatory and stress signals through transcriptional and translational mechanisms. Over the past decades, evidence has emerged suggesting that G protein-coupled receptors can recognize extracellular metabolites and regulate inflammatory responses, including eicosanoid production. This review article focuses on recent advances in metabolite G protein-coupled receptors research, their role in regulating eicosanoid biosynthesis, and their relationship to pathophysiological conditions. Chronic inflammation is a continuous low-level activation of the systemic immune response. Downstream inflammatory markers are associated with atrial fibrillation, but upstream inflammatory effectors, including eicosanoids, are less studied. Investigating the relationship between eicosanoids and atrial fibrillation. The Framingham Heart Study used liquid chromatography- mass spectrometry for the untargeted determination of 161 eicosanoids and eicosanoid-related metabolites. The association between each eicosanoid and atrial fibrillation was assessed using the Cox proportional hazards model and analysed for age, sex, height, weight, systolic/diastolic blood pressure, current smoking, antihypertensive medications, diabetes, medical history and heart disease. Adjusted for atrial fibrillation risk factors such as myocardial infarction. We adjusted multiple tests using the false discovery rate. Our study found that a higher amount of dietary fiber was associated with a reduction in fatty liver, but this effect was more pronounced in patients in the low fiber group. We found significant changes in the profile of atrial fibrillation, regardless of the amount. This may reflect positive changes in hepatic lipid metabolism. And important regulators of coronary vascular resistance, but their mechanisms of action are not fully understood. A chemo proteomic strategy using clickable photo affinity probes was applied to identify a G protein-coupled receptor as the micro vascular smooth muscle cell receptor. The former increases micro vascular smooth muscle cell receptor intracellular calcium and micro vascular coronary resistance through her GPR39 and the latter inhibits these effects. Furthermore, we find that the efficacy of both ligands is enhanced by zinc, which acts as an allosteric modulator. Coronary perfusion pressure measurements of her GPR39-null hearts using the Langendorff preparation indicate that receptors sense these eicosanoids to regulate micro vascular tone. These results suggest that GPR39 is an eicosanoid receptor and a key regulator of myocardial tissue perfusion. Our results have a significant impact on our understanding of the role of eicosanoids in cardiovascular physiology and disease and provide opportunities for the development of new her GPR39-targeted therapies for cardiovascular disease. Eicosanoids, oxygenated derivatives of polyunsaturated fatty acids, function as signalling molecules that regulate spermatogenesis in mammals. However, their role in crustacean sperm development remains unclear. In this study, the testes and vas deferens of the black tiger shrimp Penaeus monodon were analysed using ultra-performance liquid chromatography coupled with high-resolution orbitrap mass spectrometry. This led to the identification of three pufas and ten eicosanoids. The discussion focuses on an overview of coronary atherosclerosis, with emphasis on the sequences involved in the formation of atherosclerotic lesions.
None.
The author’s declared that they have no conflict of interest.
Citation: Jean K (2022) Biosynthesis of Eicosanoids Requires a Series of Catalytic Steps. Autacoids J. 3:26.
Copyright: © 2022 Jean K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.