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Commentary Article - (2023) Volume 14, Issue 1

A Thorough Survey of Glucose Biosensors in light of Nanostructured Metal-oxides
Jae Joon*
Department of Advanced Technology Fusion, Konkuk University, Korea
*Correspondence: Jae Joon, Department of Advanced Technology Fusion, Konkuk University, Korea, Email:

Received: 02-Jan-2023, Manuscript No. aasrfc-23-16709; Editor assigned: 04-Jan-2023, Pre QC No. aasrfc-23-16709 (PQ); Reviewed: 18-Jan-2023, QC No. aasrfc-23-16709; Revised: 23-Jan-2023, Manuscript No. aasrfc-23-16709 (R); Published: 30-Jan-2023, DOI: 10.36648/0976-8610.4.1.06


Nanotechnology has opened new and exciting doors for the investigation of glucose bio sensing applications of recently developed nanostructured materials. Nanostructured metal oxides have been extensively studied to create biosensors with high responsivity, fast response time and stability for glucose sensing by electrochemical oxidation. Diabetes is one of the leading causes of death and disability in the world and the leading cause of cardiovascular disease, renal failure and visual impairment. About 200 million people worldwide suffer from diabetes. This number is expected to grow to hundreds of millions by 2030. Continuous measurement of physiologic blood glucose levels to avoid the development of diabetes is important to confirm effective treatment. Therefore, the development of highly sensitive, low-cost solid-state glucose sensors with surprising selectivity has been a long-standing concern in both clinical science and the food industry. Glucose oxidase (GOx)-based glucose biosensors have often inspired the innovative development of glucose sensors and commercial centre’s in recent years. This is due to the attractiveness of precision blood glucose monitoring and blood glucose monitoring from a biological and clinical point of view. Chemical-based glucose backup still has some disadvantages. This model takes into account perturbed protein immobilization, basic working conditions such as ideal temperature and pH, finesse of synthesis, and significant cost. Amperometry is a very sensitive electrochemical technique in which the application of a constant gradient potential results in a current whose signal of interest is directly dependent on target immobilization. Glucose is oxidized at a working cathode consisting of a stable metal framed by a smoke indicator or screen print and a bio-sensing species, e.g., GOx for glucose sensing. An amperometric biosensor contains several cathodes. The previous model consists of a reference cathode and a working cathode. At high currents, the pronounced IR drop makes potential control problematic, limiting the use of two-cathode scaffolds to biosensors. Overall, the third cathode is typically served as an auxiliary counter terminal and has a large surface area that allows most of the current to flow between the counter and working terminals, while the Voltage is still present. Listed below are three glucose oxidation methods, called 1st, 2nd and 3rd generation glucose sensors, based on electrokinetic systems. Metal oxide-based nanostructured glucose sensors are playing their part in the 3rd era. It shows the original glucose sensor with oxygen as the middle section between the cathode and GOx. Oxygen is reduced by a prosthetic bond of the GOx and FADH2 redox couple, the flavin adenine dinucleotide (tendency), to form hydrogen peroxide within the line of sight of glucose. The rate of oxygen depletion corresponds to glucose foci and is assessed by estimating hydrogen peroxide expansion or decreasing oxygen fixation. Impedance-measuring biosensors are also sometimes referred to as conductivity-measuring biosensors, since conductivity is synonymous with occlusion.


We have advanced quantitative methods to assure glucose in terms of EIS estimates. In this technique, GOx was immobilized on a mercaptopropionic acid-erodible (MPA) self-assembled monolayer (SAM) customized gold terminals. Parabenzoquinone (PBQ) is used as an electron mediator and is reduced to hydroquinone (H2Q). EIS estimation showed that the charge transfer resistance (Rct) decreased as the focus of glucose increased due to the increasing thickness of the dispersive current.



Conflict Of Interest

The author states there is no conflict of interest.

Citation: Joon J (2023) A Thorough Survey of Glucose Biosensors in Light of Nanostructured Metal-oxides. Adv Appl Sci Res. 14:06.

Copyright: © 2023 Joon J. This is an open-access article distributed under the terms of the Creative Commons Attribution Li- cense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.