Damayanti Tinduh
Regenerative rehabilitation integrates regenerative technologies with rehabilitation clinical practices to restitute function and quality of life in individuals with disabilities from disease or trauma. Tissue repair and regenerative rely on the function of microRNA (miRNA), molecular silencers that enact posttranscriptional gene silencing of coding genes. Sources of cell pool for tissue repair and regeneration are diverse and provided by processes including cellular dedifferentiation, transdifferentiation and reprogramming, regulated by miRNA. In health prevention, there is an increasing attention to know more markedly the processes involved in stimulation and inhibition of miRNAs expression. Several miRNAs are essential as mediators of processes associated with exercise training adaptation.
This research revealed that specific dose of therapeutic exercise giving the impact on expression of miR-150 and miR26a. Twenty eight serum samples were taken from a healthy young males (25-35 yo) before and after underwent specific Treadmill exercise with Moderate Intensity (65-75% of maximal heart rate) Graded increased Inclination (for Active life style (A-MIGI) group (n=6) and Sedentary life style (S-MIGI) group (n=8)) versus Moderate Intensity Graded increased Speed (for Active life style (A-MIGS) group (n=6) and Sedentary life style (S-MIGS) group (n=8)) for 2 weeks. The result showed that miR-150 was upregulated only in A-MIGS group (p=0.026), but miR-26a was upregulated only in S-MIGI group (p=0.001). Previous researches showed that miR-150 upregulated the cardiovascular regeneration, CXCR4, but downregulated MMP14 and VEGF; in the other hand miR-26a have important effect in regulating osteogenic differentiation of bone marrow- and adipose derived-mesenchymal stem cells.
