Do you know how a tall tree consumes water from the root and transports water and other nutrients to the top of the tree? It is because of the huge pressure difference between the underground water and the top of the tree caused by the nano-metric channels. Nature always shows quite fascinating nano-channels in day-to-day life. Such molecular transports are some of the fundamental reasons behind life on earth. Nature is optimally designed for plumbing at that molecular level. Nanofluidic devices are one such device to identify and understand the flow of single molecules. In this research article published in the Lap on a Chip by the Royal Society of Chemistry a team of researchers goes close to nature’s ability to handle individual molecules. In this brief review, we highlight the importance of Lap on Chip devices with recent applications. In this review, the scientists showed how to use subatomic particles, like electrons, to manufacture such tiny nanochannels and identify the flow of individual single molecules inside them in a liquid phase.