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Abstract

Role of lyophilized platelet-rich plasma in lung disorders

Pradeep V Mahajan

The global burden of lung diseases is increasing steadily, with developed countries showing increasing trends in tobacco- and pollution-associ-
ated lung dysfunction, while developing countries are grappling with infectious conditions such as tuberculosis. Irrespective of the type of lung
disease obstructive, circulatory, malignant, infectious, etc. The pathogenesis ultimately leads to scarring of lung tissue, structural changes, loss
of cells, and circulatory disturbances in the lungs, all of which have long-term effects on the quality of life of the affected individual. Therefore,
the need of the hour is not just strategies that help control progression of the disease, but also those that help in regeneration of damaged
tissues. Regenerative medicine and cell-based therapies are being researched in the management of several acute and chronic conditions. One
such therapeutic modality is the use of platelet concentrates. Platelets have a complex biology that has been shown to play an important role
in inflammation and tissue repair, in addition to blood clotting. The various growth factors in platelet concentrate play roles in chemotaxis, cell
differentiation, extracellular matrix remodelling, angiogenesis, and tissue repair among other functions. In context of lung diseases, platelet
concentrates (particularly platelet-rich plasma [PRP]) can reduce alveolar as well as systemic inflammation, thereby preventing progression of
the infection. PRP has been shown to decrease the expression and production of pro-inflammatory cytokines, improve blood supply, enhance
pulmonary oxygenation, reduce fibrosis, among other effects, all of which aid in regeneration of cells and tissues in lung diseases. Lyophilization
of PRP is a consistent method for product standardization and fabrication of an off-the-shelf product with improved stability, which is ready for
future uses. In this presentation, I will explain the advantages of PRP in pulmonary regeneration and highlight the advantages of lyophilized PRP
in the management of various lung disorders including COVID-19.

Published Date: 2021-11-18;