European Journal of Experimental Biology Open Access

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Relative Influence of adrenergic �?Ž�?²-agonist and antagonist on the inflammation and their interaction with aspirin

S. S. Padgilwar and J. V. Manwar

Aim of the present study was to evaluate the effects of adrenergic β-agonist and antagonist on acute and subacute inflammation and to study their possible interaction with aspirin, a commonly used NSAID. Propranolol in the dose of 4.5 mg/kg, 9 mg/kg, atenolol in the dose of 1mg/kg and 4.5 mg/kg, terbutaline in the dose of0.45mg/kg and 0.9mg/kg and aspirin in the dose of 54,200 mg/kg were administered orally in different groups of albino rats, to study their effect on inflammation induced by carrageenan or a foreign body. Aspirin (54 mg/kg) was administered with terbutaline (0.45 mg/kg) propranolol and atenolol (4.5mg/kg and 1mg/kg) to separate groups in order to study their interaction. Terbutaline, propranolol and atenolol produced significant anti-inflammatory activity in acute as well as sub acute inflammation model except atenolol in sub acute model. Sub anti-inflammatory (low dose) dose of terbutaline potentiated the anti-inflammatory activity of aspirin where as propranolol and atenolol failed. In conclusion, adrenergic β agonist and antagonist showed significant anti-inflammatory activity and coadministration with aspirin potentiated anti-inflammatory response of aspirin.