Ðkzhonas Ermekovna Khamitova* and Dmitriy Aleksandrovich Berillo
The search for new, effective and safe (low toxicity) medicines remains an urgent problem. Many compounds containing piperidine, morpholine and piperazine series are widely used in medicine and belong to the important group of biologically active compounds. The informational and literary search was conducted for the development of new nitrogen-containing heterocyclic biologically active compounds. This review summarizes the results of piperidine, morpholine and piperazine as potential sources of biologically active substances. To analyze the ways of chemical synthesis, to study the biological activity of new biologically active compounds based on nitrogen-containing organic compounds and to consider currently known drugs based on piperidine, morpholine and piperazine. Scientific papers, review articles and patents in the field of synthesis of piperidine, morpholine and piperazine derivatives. Synthesis and determination of the biological activity of new derivatives of piperidine, morpholine and piperazine. The main search criteria were studies over the past 10 years, the inclusion criteria were the chemical synthesis and the study of the biological activity of the obtained new derivatives of piperidine, morpholine and piperazine. The chemical modification of known molecules makes it possible to create medicinal substances that have a more pronounced pharmacological effect and less side effects. The targeted synthesis and study of the pharmacological properties of new derivatives of the piperidine, morpholine, and piperazine series, which additionally contain pharmacophore groups as substituents, is of considerable theoretical and practical interest.
Published Date: 2021-12-30; Received Date: 2020-02-03
