Integrating Neuropsychological Outcomes into Clinical Studies for Treating Secondary or Primary Intracranial Malignancies in the Era of Modern Radiation Therapy
Shinn-Yn Lin, Din-Li Tsan, Chi-Cheng Chuang, Ping-Ching Pai, Yin-Yin Chiang, Chi-Cheng Yang, Yu-Jen Lu, Yin-Cheng Huang and Wen-Chi Chou
In managing patients with brain metastasis in the disciplines of neuro-oncology, neurosurgery, and radiation oncology, intracranial control and care. Of note, the controversies and problems associated with delayed radiation-related cognitive dysfunction cannot be ignored, particularly in patients who have undergone whole-brain radiation therapy (WBRT). Concerning neurocognitive consequences related to cranial irradiation, previous studies have shown that impaired hippocampal neurogenesis may be responsible for such cognitive impacts resulting from the delivery of WBRT. Therefore, it has been hypothesized that conformal hippocampal sparing during the course of WBRT (HS-WBRT) would contribute to meaningful preservation with regard to neurocognitive functions (NCFs).