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Abstract

Pattern of circulating granulocyte colony stimulating factor among trau- ma hemorrhagic shock

Manoj Kumar

Introduction: Circulating peripheral blood granulocyte colony stimulating factor (G-CSF)may contribute to the pathophysiology of bone marrow
dysfunction among trauma hemorrhagic shock patients (T/HS).However, the pattern of peripheral blood G-CSF in T/HS and trauma victim without
haemorrhagic shock (TVWHS)is not well understood. Therefore, purpose of the study was to explore circulating peripheral blood G-CSF at differ-
ent time points i.e., at day 0, 3 and 7, and its correlation with clinical outcomes in term of survival or death.
Methods: Prospective cohort study enrolled 105 patients. Blood sample from 55 T/HS patients were collected at the time of admission and fol-
low-up day 3 (n=31) and day 7 (n=19) for the determination of circulating serum levels of G-CSF. Moreover, compare with 25 healthy volunteer
and 25 TVWHS patients. Demographic details were collected, and whether patient was in shock. Laboratory parameters were also recorded.
Results: Elevated circulating levels of G-CSF at day 0 (at the time of admission) when compared with day 3 and 7 [255 (102.5-696.6) vs 125 (75-
202.5) vs 147.5 (118.75-316.25),p<0.001)]. G-CSF were also elevated in T/HS when compared with TVWHS and healthy volunteer (2691.2±41.6
vs. 1980.0±48.0, p<0.001, and 2691.2±41.6 vs.183.7±35, p<0.001). Elevated serum level of G-CSF were also found in TVWHS when compared with
healthy volunteer (1980.0±48.0 vs. 183.7±35, p<0.001).
Conclusions: Circulating G-CSF is markedly elevated after traumatic injury and is greater in patients who present in T/HS. Elevated circulating
G-CSF was also associated with prolonged mobilization of hematopoietic progenitor cells (HPC). Elevation of G-CSF in humans following T/HS and
TVWHS may play a significant role in the development of post traumatic bone marrow dysfunction (BMD), anaemia and infection.

Published Date: 2021-11-18;